School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China.
J Ethnopharmacol. 2019 Mar 1;231:152-169. doi: 10.1016/j.jep.2018.10.040. Epub 2018 Nov 5.
Angelica biserrata (R.H. Shan & C.Q. Yuan) C.Q. Yuan & R.H. Shan (Angelica pubescens Maxim. f. biserrata Shan et Yuan) (A.biserrata) is a widely used traditional Chinese medicine; its roots known as 'Duhuo' in China. The herb is used for expelling wind, eliminating dampness, and terminating pain. Moreover, it is used for treating the onset of anemofrigid-damp arthralgia, pain of the waist and knee and headache caused by latent wind pathogenic factor or damp-cold pathogenic factor. A.biserrata is slightly warm, bitter and pungent in taste, and it is well distributed in regions such as Sichuan and Hubei Provinces.
This review aims to provide critical summary of the current evidence on A.biserrata. In particular, the progress of studies in the fields of botany, ethnopharmacology, phytochemistry, pharmacology and toxicity are discussed. Possible directions for future research are also briefly proposed.
Information on A.biserrata was collected from the internet database PubMed, Elsevier, China Knowledge Resource Integrated databases, ResearchGate, Web of Science, Wiley Online Library and Europe PMC using a combination of various relevant keywords. Other published books providing an overview of extant literature studies were considered for reference if they are related to the taxonomy, traditional knowledge, phytochemistry, pharmacology and toxicity of the plant.
A substantial proportion of the isolated and identified compounds of the herb were reported to be coumarins and volatile oils. Biological effects, such as neuroprotective, anti-tumor, anti-arthritis, anti-inflammatory, and sedative, were also validated in In vitro and in vivo studies. Therapeutic effects are attributed to the bioactivities of the naturally occurring compounds in this herb.
A.biserrata has been proven as a valuable medicinal sources from traditional herb. Some conventional uses has been evaluated by pharmacological investigation. Although the crude extracts of A.biserrata has been emerged to possess more pharmacological activities, it is now time to isolate and identify more active chemical constituents by Bioactivity-Guided and elucidate their structure-activity relationship. More designed investigations are need to focus on understanding the multi-target network pharmacology, clarity the molecular mechanism of action and efficacy as well as identifying the effective doses of A.biserrata. In addition, A.biserrata is not fully assessed regarding its safety. Further studies are essential to investigate its toxicity on human. It's useful to provide identify its underlying therapeutic remedy and economic value of developing new medicine in the future.
当归（R.H. Shan & C.Q. Yuan）C.Q. Yuan & R.H. Shan（当归 pubescens Maxim. f. biserrata Shan et Yuan）（A.biserrata）是一种广泛使用的中药；其根在中国被称为“独活”。该草药用于祛风除湿、止痛。此外，它还用于治疗风寒湿痹、腰膝疼痛、头痛等症，这些病症是由潜伏的风邪或寒湿引起的。A.biserrata 性微温，味辛苦，分布于四川、湖北等地。
本综述旨在对 A.biserrata 的现有证据进行批判性总结。特别是，讨论了植物学、民族药理学、植物化学、药理学和毒理学领域研究进展。还简要提出了未来研究的可能方向。
从互联网数据库 PubMed、Elsevier、中国知识资源综合数据库、ResearchGate、Web of Science、Wiley Online Library 和 Europe PMC 中收集了关于 A.biserrata 的信息，使用各种相关关键词组合进行检索。如果与植物的分类学、传统知识、植物化学、药理学和毒理学有关，还会参考其他提供文献综述的出版书籍。
从该草药中分离和鉴定的化合物中，有相当一部分是香豆素和挥发油。在体外和体内研究中也验证了神经保护、抗肿瘤、抗关节炎、抗炎和镇静等生物学效应。这些治疗效果归因于该草药中天然存在的化合物的生物活性。
A.biserrata 已被证明是一种有价值的传统药用植物资源。一些传统用途已通过药理学研究进行了评估。虽然 A.biserrata 的粗提取物已被证明具有更多的药理活性，但现在是时候通过生物活性导向分离和鉴定更多具有活性的化学物质，并阐明它们的结构-活性关系了。需要更多有针对性的研究来关注理解多靶点网络药理学、明确作用机制和疗效的分子机制以及确定 A.biserrata 的有效剂量。此外，A.biserrata 的安全性尚未得到充分评估。进一步的研究对于研究其对人类的毒性至关重要。这有助于确定其潜在的治疗方法和未来开发新药的经济价值。
