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Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.环氧化酶-2衍生的前列腺素E2通过EP1受体介导的表皮生长因子受体和Akt激活促进人胆管癌细胞的生长和侵袭。
J Biol Chem. 2015 Jul 17;290(29):17806. doi: 10.1074/jbc.A115.500562.
2
Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.环氧化酶-2衍生的前列腺素E2通过EP1受体介导的表皮生长因子受体和Akt激活促进人胆管癌细胞的生长和侵袭。
J Biol Chem. 2005 Jun 24;280(25):24053-63. doi: 10.1074/jbc.M500562200. Epub 2005 Apr 26.
3
Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor.前列腺素E2通过EP3 - 4受体上调β-连环蛋白表达，促进人胆管癌细胞的增殖、迁移和侵袭。
Oncol Rep. 2015 Aug;34(2):715-26. doi: 10.3892/or.2015.4043. Epub 2015 Jun 9.
4
Prostaglandin E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells: involvement of EP1 receptor, calcium and EGF receptors signaling.前列腺素E2增强人胆管癌细胞中的丝裂原活化蛋白激酶/细胞外信号调节激酶通路：EP1受体、钙和表皮生长因子受体信号的参与
Mol Cell Biochem. 2007 Nov;305(1-2):19-26. doi: 10.1007/s11010-007-9523-5. Epub 2007 Jun 6.
5
A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.过氧化物酶体增殖物激活受体δ与前列腺素E2信号通路之间存在一种新型正反馈环，可促进人胆管癌细胞生长。
J Biol Chem. 2006 Nov 10;281(45):33982-96. doi: 10.1074/jbc.M600135200. Epub 2006 Sep 11.
6
Prostaglandin E2 upregulates survivin expression via the EP1 receptor in hepatocellular carcinoma cells.前列腺素 E2 通过肝癌细胞中的 EP1 受体上调生存素的表达。
Life Sci. 2010 Jan 30;86(5-6):214-23. doi: 10.1016/j.lfs.2009.12.009. Epub 2009 Dec 24.
7
Tumor necrosis factor-alpha upregulates the prostaglandin E2 EP1 receptor subtype and the cyclooxygenase-2 isoform in cultured amnion WISH cells.肿瘤坏死因子-α上调培养的羊膜WISH细胞中前列腺素E2 EP1受体亚型和环氧化酶-2同工型。
J Interferon Cytokine Res. 1998 Dec;18(12):1039-44. doi: 10.1089/jir.1998.18.1039.
8
Transforming growth factor-beta (TGF-beta) activates cytosolic phospholipase A2alpha (cPLA2alpha)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated receptor-gamma (PPAR-gamma)/Smad signaling pathways in human liver cancer cells. A novel mechanism for subversion of TGF-beta-induced mitoinhibition.转化生长因子-β（TGF-β）激活人肝癌细胞中胞质磷脂酶A2α（cPLA2α）介导的前列腺素E2（PGE）2/EP1和过氧化物酶体增殖物激活受体-γ（PPAR-γ）/Smad信号通路。一种颠覆TGF-β诱导的有丝分裂抑制的新机制。
J Biol Chem. 2004 Oct 22;279(43):44344-54. doi: 10.1074/jbc.M404852200. Epub 2004 Aug 4.
9
Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway.通过抑制前列腺素E2受体EP1实现的神经保护作用涉及PTEN/AKT信号通路。
Neurobiol Dis. 2008 Mar;29(3):543-51. doi: 10.1016/j.nbd.2007.11.010. Epub 2007 Dec 4.
10
Prostaglandin E₂ receptor EP1-mediated phosphorylation of focal adhesion kinase enhances cell adhesion and migration in hepatocellular carcinoma cells.前列腺素 E₂ 受体 EP1 介导的粘着斑激酶磷酸化增强肝癌细胞的黏附和迁移。
Int J Oncol. 2013 May;42(5):1833-41. doi: 10.3892/ijo.2013.1859. Epub 2013 Mar 20.

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Identification and validation of a novel ferroptosis-related gene signature for prognosis and potential therapeutic target prediction in cholangiocarcinoma.鉴定和验证新型铁死亡相关基因特征，用于预测胆管癌的预后和潜在治疗靶点。
Front Immunol. 2023 Jan 17;13:1051273. doi: 10.3389/fimmu.2022.1051273. eCollection 2022.
2
Probing the Anti-Cancer Potency of Sulfated Galactans on Cholangiocarcinoma Cells Using Synchrotron FTIR Microspectroscopy, Molecular Docking, and In Vitro Studies.利用同步辐射傅里叶变换红外显微镜、分子对接和体外研究探测硫酸化半乳糖对胆管癌细胞的抗癌活性。
Mar Drugs. 2021 Apr 30;19(5):258. doi: 10.3390/md19050258.
3
ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.胆管癌中的ErBb家族蛋白及其临床意义。
J Clin Med. 2020 Jul 16;9(7):2255. doi: 10.3390/jcm9072255.
4
Alterations of COX-2, HER-2/neu and E-Cadherin protein expression in the prostatic adenocarcinoma: preliminary findings.前列腺腺癌中COX-2、HER-2/neu和E-钙黏蛋白蛋白表达的改变：初步研究结果。
Am J Transl Res. 2019 Mar 15;11(3):1653-1667. eCollection 2019.
5
PGE /EP receptor attenuated mucosal injury via β-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy.前列腺素E/前列腺素E受体通过β-抑制蛋白1/肉瘤病毒癌基因/表皮生长因子受体介导的增殖减轻门静脉高压性胃病中的黏膜损伤。
Br J Pharmacol. 2017 May;174(9):848-866. doi: 10.1111/bph.13752. Epub 2017 Mar 25.
6
The ω-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of β-catenin complex, inhibiting COX-2 through repressing NF-κB, and inducing 15-prostaglandin dehydrogenase.ω-3多不饱和脂肪酸通过阻断β-连环蛋白复合物的解离、通过抑制核因子κB来抑制环氧化酶-2以及诱导15-前列腺素脱氢酶，从而预防结肠炎相关的癌变。
Oncotarget. 2016 Sep 27;7(39):63583-63595. doi: 10.18632/oncotarget.11544.

Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.

作者信息

Han Chang, Wu Tong

出版信息

J Biol Chem. 2015 Jul 17;290(29):17806. doi: 10.1074/jbc.A115.500562.

DOI:10.1074/jbc.A115.500562
PMID:26188043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4505029/
Abstract
摘要