长期改善轻度囊性纤维化肺病患者的肺清除指数：高渗盐水是否起作用？

Long-term improvement of lung clearance index in patients with mild cystic fibrosis lung disease: Does hypertonic saline play a role?

机构信息

Medical University of Innsbruck, Department of Child and Adolescent Health, Division of Cardiology, Pulmonology, Allergology, and Cystic Fibrosis, Cystic Fibrosis Centre, Anichstrasse 35, A-6020 Innsbruck, Austria.

出版信息

J Cyst Fibros. 2016 Jan;15(1):123-6. doi: 10.1016/j.jcf.2015.06.009. Epub 2015 Jul 17.

DOI:10.1016/j.jcf.2015.06.009

PMID:26190829

Abstract

To assess whether long-term inhalation with hypertonic saline is able to halt the progression of mild CF lung disease, we analysed longitudinal data of lung clearance index (LCI) and spirometry. A total of 34 patients with mild lung disease (FEV1 ≥ 70% of predicted) had at least one LCI result before and ≥2 LCI measurements after start of hypertonic saline (HS) therapy. After a mean follow-up of 39.7 (SD 7.4) months after starting HS, LCI improved significantly from 7.89 (SD 1.35) at baseline to 6.96 (SD 1.03), and 19/34 patients had a normal LCI value at the last measurement. No decrease in mean FEV1 was observed. Thus, ventilation inhomogeneity can improve in patients with mild lung disease.

摘要

为了评估长期吸入高渗盐水是否能够阻止轻度 CF 肺病的进展，我们分析了肺清除指数（LCI）和肺活量计的纵向数据。共有 34 名轻度肺病患者（FEV1 ≥预测值的 70%）在开始高渗盐水（HS）治疗前至少有一次 LCI 结果，并且在开始后≥2 次 LCI 测量。在开始 HS 后平均随访 39.7（SD 7.4）个月后，LCI 从基线时的 7.89（SD 1.35）显著改善至 6.96（SD 1.03），并且最后一次测量时有 19/34 名患者的 LCI 值正常。平均 FEV1 没有下降。因此，轻度肺病患者的通气不均匀性可以改善。