Chindo Ben A, Kahl Evelyn, Trzeczak Doris, Dehmel Petra, Becker Axel, Fendt Markus
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria; Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research & Development, Abuja, Nigeria.
Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Behav Brain Res. 2015 Oct 15;293:74-80. doi: 10.1016/j.bbr.2015.06.044. Epub 2015 Jul 17.
Preparations of Ficus platyphylla are used in Nigeria's folk medicine to manage a plethora of diseases including, insomnia, psychoses, depression, epilepsy, pain and inflammation. In this study, we examined the effects of the standardized methanol extract of F. platyphylla stem bark (FP) on apomorphine-induced changes in prepulse inhibition and locomotor activity in rats, as well as on the retrieval of a conditioned reaction in one-way active avoidance in mice. FP did not affect basal prepulse inhibition, but significantly reduced locomotor activity. The apomorphine-induced prepulse inhibition deficit and hyperactivity were significantly reversed by co-administration of clozapine or FP. Furthermore, FP inhibited the retrieval of a conditioned avoidance reaction. Our results revealed that FP contains psychoactive ingredients with neuroleptic-like properties, thus supporting the isolation and development of the biologically active components of this medicinal plant as antipsychotic agents.
阔叶榕制剂在尼日利亚民间医学中用于治疗多种疾病，包括失眠、精神病、抑郁症、癫痫、疼痛和炎症。在本研究中，我们研究了阔叶榕茎皮标准化甲醇提取物（FP）对阿扑吗啡诱导的大鼠前脉冲抑制和运动活动变化的影响，以及对小鼠单向主动回避中条件反应恢复的影响。FP不影响基础前脉冲抑制，但显著降低运动活动。氯氮平或FP联合给药可显著逆转阿扑吗啡诱导的前脉冲抑制缺陷和多动。此外，FP抑制条件回避反应的恢复。我们的结果表明，FP含有具有抗精神病样特性的精神活性成分，从而支持将这种药用植物的生物活性成分分离和开发为抗精神病药物。
