肥胖对白人女性的血清抗苗勒管激素（AMH）水平有不利影响。
Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women.
作者信息
Moy Vicky, Jindal Sangita, Lieman Harry, Buyuk Erkan
机构信息
Department of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Block Building Room 630, Bronx, NY, 10461, USA.
Montefiore's Institute for Reproductive Medicine and Health, Hartsdale, NY, USA.
出版信息
J Assist Reprod Genet. 2015 Sep;32(9):1305-11. doi: 10.1007/s10815-015-0538-7. Epub 2015 Jul 21.
OBJECTIVE
Previous studies regarding the effect of obesity on serum anti-müllerian hormone (AMH) levels have been conflicting. Our aim was to determine the effect of obesity on serum AMH levels among women from different racial backgrounds.
METHODS
The medical records of 350 women (159 Caucasian, 99 African-American, 58 Hispanic, 34 Asian with ages 16-46) evaluated for infertility at an academic-affiliated center and who had AMH levels measured as part of their evaluation were reviewed. Age, AMH, body mass index (BMI), self-reported race, etiology of infertility, smoking history, maximum serum early follicular follicle-stimulating hormone (FSH) levels, antral follicle count (AFC), and history of ovarian surgery, chemotherapy, or radiotherapy were recorded.
RESULTS
Age correlated negatively with AMH and antral follicle count across all races (p < 0.05). After adjusting for age, polycystic ovary syndrome diagnosis, and smoking, elevated BMI had a negative correlation with AMH in Caucasian women (β = 0.17, p = 0.01) but not in African-American, Hispanic, or Asian women.
CONCLUSION
Elevated BMI correlates negatively with AMH in Caucasian women but not in African-American, Hispanic, or Asian women. Additional studies are needed to elucidate further the effect of race on the interaction between obesity and ovarian reserve.
目的
以往关于肥胖对血清抗苗勒管激素（AMH）水平影响的研究结果相互矛盾。我们的目的是确定肥胖对不同种族背景女性血清AMH水平的影响。
方法
回顾了在一家学术附属中心接受不孕症评估且作为评估一部分测量了AMH水平的350名女性（159名白种人、99名非裔美国人、58名西班牙裔、34名亚洲人，年龄在16 - 46岁之间）的病历。记录了年龄、AMH、体重指数（BMI）、自我报告的种族、不孕病因、吸烟史、血清早期卵泡期促卵泡激素（FSH）最高水平、窦卵泡计数（AFC）以及卵巢手术、化疗或放疗史。
结果
在所有种族中，年龄与AMH和窦卵泡计数呈负相关（p < 0.05）。在调整年龄、多囊卵巢综合征诊断和吸烟因素后，BMI升高在白种女性中与AMH呈负相关（β = 0.17，p = 0.01），但在非裔美国女性、西班牙裔女性或亚洲女性中并非如此。
结论
BMI升高在白种女性中与AMH呈负相关，但在非裔美国女性、西班牙裔女性或亚洲女性中并非如此。需要进一步研究以阐明种族对肥胖与卵巢储备之间相互作用的影响。
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