Department of Pediatrics, Albert Einstein College of Medicine, Montefiore Medical Center, 111 E. 210th Street, Bronx, NY 10467, USA.
Metabolism. 2012 Sep;61(9):1261-9. doi: 10.1016/j.metabol.2012.02.005. Epub 2012 Mar 22.
Differences in adipose tissue secretory profile, as measured by adipokine levels, may play a role in race-ethnic disparities in cardiovascular disease (CVD). We examined race-ethnic differences in adipokine levels in a group of mid-life Caucasian, African American (AA), Chinese and Japanese women, after accounting for adiposity. Data on 1876 women from the Study of Women's Health Across the Nation were analyzed. In multivariable adjustment, including total fat mass, differences in total and high molecular weight (HMW) adiponectin, leptin and soluble leptin receptor (sOB-R) levels were examined. Despite intermediate levels of adiposity, Caucasian women had higher levels of both total and HMW adiponectin, when compared to both AA and Chinese and Japanese women. After multivariable adjustment, compared to Caucasian women, AA women had significantly lower total (β: -3.40; 95% CI: -4.29, -2.52; P<.001) and HMW adiponectin (β: -0.53; 95% CI: -0.64, -0.43; P<.001) levels, higher leptin levels (β: 3.26; 95% CI: 1.36, 5.16; P<.001) and lower sOB-R levels (β: -0.07; 95% CI: -0.11, -0.03; P<.001). Compared to Caucasian women, both Chinese and Japanese women had lower total (Chinese: β: -5.50; 95% CI: -7.07, -3.93; P<.001; Japanese: β: -5.48; 95% CI: -6.95, -4.02; P<.001) and HMW adiponectin (Chinese: β: -0.57; 95% CI: -0.75, -0.38; P<.001; Japanese: β: -0.61; 95% CI: -0.78, -0.44; P<.001) levels and lower sOB-R levels (Chinese: β: -0.13; 95% CI: -0.20, -0.06; P<.001; Japanese: β: -0.09; 95% CI: -0.15, -0.02; P=.008). Significant race-ethnic differences exist in circulating adipokines, even after accounting for adiposity. Further research is needed to explicitly determine if such differences contribute to known racial differences in CVD risk.
种族-民族差异可能在心血管疾病（CVD）的种族差异中发挥作用，这可以体现在脂肪组织分泌特征的差异上，通过脂联素水平可以衡量。我们研究了中年白种人、非裔美国人（AA）、中国和日本女性的种族-民族之间的脂联素水平差异，这些差异在考虑到体脂的情况下进行了评估。这项研究的数据来自国家妇女健康研究。在多变量调整中，包括总脂肪量，检查了总脂联素和高分子量（HMW）脂联素、瘦素和可溶性瘦素受体（sOB-R）水平的差异。尽管体脂水平处于中等水平，与 AA 和中国及日本女性相比，白种女性的总脂联素和 HMW 脂联素水平均更高。在多变量调整后，与白种女性相比，AA 女性的总脂联素（β：-3.40；95%置信区间：-4.29，-2.52；P<.001）和 HMW 脂联素（β：-0.53；95%置信区间：-0.64，-0.43；P<.001）水平显著降低，瘦素水平（β：3.26；95%置信区间：1.36，5.16；P<.001）升高，sOB-R 水平（β：-0.07；95%置信区间：-0.11，-0.03；P<.001）降低。与白种女性相比，中国和日本女性的总脂联素（中国：β：-5.50；95%置信区间：-7.07，-3.93；P<.001；日本：β：-5.48；95%置信区间：-6.95，-4.02；P<.001）和 HMW 脂联素（中国：β：-0.57；95%置信区间：-0.75，-0.38；P<.001；日本：β：-0.61；95%置信区间：-0.78，-0.44；P<.001）水平和 sOB-R 水平（中国：β：-0.13；95%置信区间：-0.20，-0.06；P<.001；日本：β：-0.09；95%置信区间：-0.15，-0.02；P=.008）均较低。即使考虑到体脂，循环脂联素也存在显著的种族-民族差异。需要进一步的研究来明确这些差异是否导致已知的 CVD 风险的种族差异。
