儿科心脏网络：应对儿科心脏病多中心研究的挑战
The pediatric heart network: meeting the challenges to multicenter studies in pediatric heart disease.
作者信息
Burns Kristin M, Pemberton Victoria L, Pearson Gail D
机构信息
National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA.
出版信息
Curr Opin Pediatr. 2015 Oct;27(5):548-54. doi: 10.1097/MOP.0000000000000260.
Abstract
PURPOSE OF REVIEW
Because of the relatively small numbers of pediatric patients with congenital heart disease cared for in any individual center, there is a significant need for multicenter clinical studies to validate new medical or surgical therapies. The Pediatric Heart Network (PHN), with 15 years of experience in multicenter clinical research, has tackled numerous challenges when conducting multicenter studies.
RECENT FINDINGS
This review describes the challenges encountered and the strategies employed to conduct high-quality, collaborative research in pediatric cardiovascular disease.
SUMMARY
Sharing lessons learned from the PHN can provide guidance to investigators interested in conducting pediatric multicenter studies.
摘要
综述目的
由于在任何单个中心接受治疗的先天性心脏病儿科患者数量相对较少，因此迫切需要开展多中心临床研究以验证新的药物或手术治疗方法。拥有15年多中心临床研究经验的儿科心脏网络（PHN）在开展多中心研究时面临诸多挑战。
最新发现
本综述描述了在儿科心血管疾病中开展高质量协作研究时遇到的挑战及采用的策略。
总结
分享从PHN获得的经验教训可为有兴趣开展儿科多中心研究的研究者提供指导。
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