Zhang Zhi-Xin, Zhu Bo-Han, Xie Pei-Xi, Tang Jia-Qi, Li Xin-Ling, Zhu Chunyin, Yin Ying-Wu, Ye Long-Wu
State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 China
School of Chemistry and Chemical Engineering, Jiangsu University Zhenjiang 212013 China
RSC Adv. 2018 May 18;8(33):18308-18315. doi: 10.1039/c8ra03842b. eCollection 2018 May 17.
A novel and efficient scandium-catalyzed oxidative reaction between ynamides and alcohols for the facile synthesis of various α-alkoxyl amides is reported in this paper. The reaction avoids the need for the use of α-diazo carbonyls which are unstable and may cause some safety concerns. Instead, by using alkynes as the starting materials, this protocol features readily available substrates, compatibility with a broad range of functional groups, simple procedure, mild reaction conditions, and high chemoselectivity.
本文报道了一种新颖且高效的钪催化的炔酰胺与醇之间的氧化反应，用于简便地合成各种α-烷氧基酰胺。该反应无需使用不稳定且可能引起一些安全问题的α-重氮羰基化合物。相反，通过使用炔烃作为起始原料，该方法具有底物易于获得、与多种官能团兼容、操作步骤简单、反应条件温和以及化学选择性高的特点。
