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八叠球菌,肥胖症时代的新威胁。

Sarcina, a new threat in the bariatric era.

作者信息

Sopha Sabrina C, Manejwala Alif, Boutros Cherif N

机构信息

Department of Pathology, University of Maryland Baltimore Washington Medical Center, Glen Burnie, MD 21061.

Department of Gastroenterology, University of Maryland Baltimore Washington Medical Center, Glen Burnie, MD 21061.

出版信息

Hum Pathol. 2015 Sep;46(9):1405-7. doi: 10.1016/j.humpath.2015.05.021. Epub 2015 Jun 5.

Abstract

First identified in humans by Goodsir in 1842, Sarcina were already known to cause fatal abomasal bloat in animals. Their pathogenicity in humans has only recently been characterized. Sarcina is not inherently pathogenic but, with a gastric ulcer and delayed gastric emptying, can result in perforation. We present a case report of a 32-year-old woman status post-gastric banding presenting with epigastric pain. Upper endoscopy revealed a gastric ulcer near the band. After deflation, upper gastrointestinal series showed passage of contrast and no perforation. Ulcer biopsy showed gastric contents composed of Sarcina. Proton pump inhibitors and antibiotics were administered. Follow-up endoscopy at an outside institution resulted in perforation. This case report supports a growing body of literature that Sarcina organisms contribute to ulcers and perforation. This is the first report of Sarcina in elective bariatric surgery patients, highlighting the high suspicion needed among pathologists evaluating ulcers in this unique surgical population.

摘要

1842年古德西尔首次在人类身上发现八叠球菌,当时已知其会导致动物致命性皱胃臌气。其对人类的致病性直到最近才得以明确。八叠球菌本身并无致病性,但在存在胃溃疡和胃排空延迟的情况下,可导致胃穿孔。我们报告一例32岁接受胃束带手术的女性,出现上腹部疼痛。上消化道内镜检查发现束带附近有胃溃疡。放气后,上消化道造影显示造影剂通过且无穿孔。溃疡活检显示胃内容物中有八叠球菌。给予质子泵抑制剂和抗生素治疗。在外部机构进行的后续内镜检查导致了穿孔。该病例报告支持了越来越多的文献观点,即八叠球菌可导致溃疡和穿孔。这是八叠球菌在择期减肥手术患者中的首例报告,凸显了病理学家在评估这一独特手术人群中的溃疡时需要高度怀疑。

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