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低分子肝素诱导的组织坏死:一例报告及文献综述

Lovenox Induced Tissue Necrosis, a Case Report and Literature Review.

作者信息

Issa Abdelfatah Abou, Simman Richard

机构信息

Pharmacology & Toxicology Department, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.

Pharmacology & Toxicology Department, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA ; Plastic and Reconstructive Surgery, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.

出版信息

J Am Coll Clin Wound Spec. 2015 Mar 18;5(3):66-8. doi: 10.1016/j.jccw.2015.03.001. eCollection 2013 Dec.

Abstract

Lovenox is a trade name for Enoxaparin. It is a low molecular weight heparin (LMWH) and has other trade names like Clexane and Xaparin. It is an anticoagulant used to prevent and treat venous thromboembolism events (VTE) like deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection. General speaking, the most common skin reactions as a result of enoxaparin use are: urticarial, ecchymosis, and even skin necrosis due to vasculitis. These side effects are usually located at the injection site. New studies have pointed out the side effect that could occur a distance from the site of Lovenox injection. In our case extensive skin and subcutaneous tissue necrosis developed at the abdominal wall injection site.

摘要

洛伐凝是依诺肝素的商品名。它是一种低分子量肝素(LMWH),还有其他商品名,如克赛和速碧林。它是一种抗凝剂,用于预防和治疗静脉血栓栓塞事件(VTE),如深静脉血栓形成或肺栓塞,通过皮下注射给药。一般来说,使用依诺肝素最常见的皮肤反应有:荨麻疹、瘀斑,甚至因血管炎导致的皮肤坏死。这些副作用通常发生在注射部位。新的研究指出了可能在洛伐凝注射部位以外出现的副作用。在我们的病例中,腹壁注射部位出现了广泛的皮肤和皮下组织坏死。

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本文引用的文献

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Enoxaparin-induced hemorrhagic bullous dermatosis in a leprosy patient.
Cutan Ocul Toxicol. 2015;34(3):254-6. doi: 10.3109/15569527.2014.950381. Epub 2014 Sep 8.
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Drug-induced dilemma: angiokeratomas and decreased renal function.
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Heparin-induced thrombocytopenia: a review.肝素诱导的血小板减少症:综述
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