Katsourakis Anastasios, Noussios George, Kapoutsis George, Chatzitheoklitos Efthimios
Department of Surgery, "Agios Dimitrios" General Hospital of Thessaloniki, 54627 Thessaloniki, Greece.
Case Rep Med. 2011;2011:857391. doi: 10.1155/2011/857391. Epub 2011 May 30.
Low molecular weight heparins (LMWHs) are the standard agents used for antithrombotic therapy and prophylaxis. Despite their widespread use, reports about adverse effects from LMWHs are very scarce. Heparin-induced skin necrosis at the injection site is a rare adverse effect, more commonly associated with unfractionated heparin (UFH) rather than with LMWH, while its mechanism remains unclear. This paper deals with the enoxaparin induced skin necrosis.
低分子量肝素(LMWHs)是用于抗血栓治疗和预防的标准药物。尽管它们被广泛使用,但关于低分子量肝素不良反应的报道却非常稀少。注射部位肝素诱导的皮肤坏死是一种罕见的不良反应,更常见于普通肝素(UFH)而非低分子量肝素,但其机制仍不清楚。本文探讨依诺肝素诱导的皮肤坏死。