Ozsurekci Yasemin, Unal Sule, Cetin Mualla, Gumruk Fatma
Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey -
Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Minerva Pediatr. 2019 Oct;71(5):449-454. doi: 10.23736/S0026-4946.17.04268-2. Epub 2015 Jul 22.
The purpose of this study was to compare the effectiveness of different oral iron preparations in children with iron deficiency anemia (IDA).
Sixty children with IDA, aged between 6 months and 180 months, were randomly assigned into three treatment groups. Group I included children with IDA who received ferrous sulfate (Fe-S); Group II included children receiving iron polymaltose complexes (Fe-OH-PM), and Group III included children receiving a single preparation of combined iron and zinc (Fe-Zn). The effect of different iron preparations were evaluated and compared. The duration of treatment was 8 weeks. Hemoglobin (Hgb) levels, as well as other hematological parameters were determined at admission and the first, fourth, and eighth weeks of the treatment.
The Hgb levels of patients in all three groups were statistically higher in the fourth (P=0.001) and eighth (P<0.001) weeks compared to baseline; although there was no difference between the groups at the end of the treatment period (P>0.05).
Our results indicate that, Fe-OH-PM and Fe-Zn preparations may also be preferred as a choice like Fe-S for treatment of children with IDA.
本研究的目的是比较不同口服铁制剂对缺铁性贫血（IDA）患儿的疗效。
60例年龄在6个月至180个月之间的IDA患儿被随机分为三个治疗组。第一组为接受硫酸亚铁（Fe-S）的IDA患儿；第二组为接受聚麦芽糖铁复合物（Fe-OH-PM）的患儿，第三组为接受铁锌复合单一制剂（Fe-Zn）的患儿。对不同铁制剂的效果进行评估和比较。治疗持续时间为8周。在入院时以及治疗的第1、4和8周测定血红蛋白（Hgb）水平以及其他血液学参数。
与基线相比，所有三组患者在第4周（P=0.001）和第8周（P<0.001）时的Hgb水平在统计学上均更高；尽管在治疗期结束时各组之间无差异（P>0.05）。
我们的结果表明，对于治疗IDA患儿，Fe-OH-PM和Fe-Zn制剂也可能像Fe-S一样被优先选用。
