Ayoub Ashraf, Al-Fotawei Randa
The University of Glasgow Dental Hospital and School, Glasgow, UK.
Front Oral Biol. 2015;17:101-14. doi: 10.1159/000381700. Epub 2015 Jul 20.
Reconstruction of maxillofacial bones has proven to be complex due to the aesthetic requirements and functional demands of the jaw. Although autogenous bone grafts and a wide range of biomaterials are routinely used for facial bone reconstruction, these methods are associated with a number of drawbacks, including the limited availability of autogenous grafts and the morbidity associated with bone graft harvesting, whilst biomaterials are also linked with a high failure rate. These limitations have inspired the search for innovative techniques for bone bioengineering and the development of more reliable biomaterials. Tissue engineering approaches yield powerful tools for long-term satisfying results enabling customized reconstruction and the support of natural healing processes. There is no doubt that further advances in tissue engineering are essential to achieve reliable and satisfactory clinical outcomes for patients. This chapter will highlight the clinical application of biomaterials and provide an overview of the current scientific concepts in the field.
由于颌骨的美学要求和功能需求，颌面骨重建已被证明是复杂的。尽管自体骨移植和多种生物材料通常用于面部骨重建，但这些方法存在许多缺点，包括自体移植物的可用性有限以及与骨移植采集相关的发病率，而生物材料也与高失败率相关。这些局限性激发了人们对骨生物工程创新技术的探索以及更可靠生物材料的开发。组织工程方法产生了强大的工具，可带来长期令人满意的结果，实现定制化重建并支持自然愈合过程。毫无疑问，组织工程的进一步进展对于为患者实现可靠且令人满意的临床结果至关重要。本章将重点介绍生物材料的临床应用，并概述该领域当前的科学概念。
