Costantino Peter D, Hiltzik David, Govindaraj Satish, Moche Jason
Department of Otolaryngology, Mount Sinai Medical Center, New York, NY, USA.
Facial Plast Surg. 2002 Feb;18(1):13-26. doi: 10.1055/s-2002-19823.
With the advent of new biomaterials and surgical techniques, the reconstructive surgeon has a wider range of treatment modalities for the rehabilitation and reconstruction of craniofacial skeletal deformities than ever before. These innovative substances act as true bone graft substitutes, thereby allowing the surgeon to avoid the use of autogenous bone grafts and their associated donor site morbidity. Surgeons have long been interested in producing a composite graft that can heal faster by induction, incorporate with surrounding tissues, and be remodeled to resemble native bone. Currently, there are a host of bone graft substitutes available that vary in both their composition and properties. Craniomaxillofacial surgeons must therefore become comfortable with numerous biomaterials to best tailor the treatment for each patient individually. Ongoing investigations into the next phase of tissue engineering will continue to bring us closer to the ability to regenerate or replace bone.
随着新型生物材料和外科技术的出现，与以往相比，重建外科医生在颅面骨骼畸形的康复和重建方面拥有更广泛的治疗方式。这些创新物质可作为真正的骨移植替代物，从而使外科医生避免使用自体骨移植及其相关的供区并发症。长期以来，外科医生一直致力于制造一种复合移植物，这种移植物能够通过诱导更快地愈合，与周围组织融合，并重塑成类似天然骨的形态。目前，有许多骨移植替代物可供选择，它们的成分和特性各不相同。因此，颅颌面外科医生必须熟悉多种生物材料，以便为每位患者量身定制最佳治疗方案。对组织工程下一阶段的持续研究将继续使我们更接近再生或替代骨骼的能力。
