Tavares B M, Cunha F Q, Ferreira S H
Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1989;22(6):733-6.
Intravenous injections of lipopolysaccharide (LPS, 20 micrograms/kg) and of a factor originating from LPS-stimulated macrophage monolayers (Neutrophil Recruitment Inhibitory Factor, NRIF) inhibited neutrophil migration into peritoneal cavities induced by carrageenin in rats for up to 24 h. Mononuclear cell migration induced by thioglycollate was also inhibited by the same treatment with LPS but was not affected by NRIF. We conclude that NRIF specifically blocks neutrophil migration and we suggest that NRIF released into the circulation may constitute an important determinant of septicemia.
静脉注射脂多糖（LPS，20微克/千克）以及源自LPS刺激的巨噬细胞单层的一种因子（中性粒细胞募集抑制因子，NRIF），可在长达24小时内抑制角叉菜胶诱导的大鼠中性粒细胞向腹腔的迁移。LPS的相同处理也抑制了巯基乙酸盐诱导的单核细胞迁移，但NRIF对其没有影响。我们得出结论，NRIF特异性地阻断中性粒细胞迁移，并且我们认为释放到循环中的NRIF可能是败血症的一个重要决定因素。
