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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Moraes J R, Moraes F R, Bechara G H

Departamento de Patologia Veterinária, Faculdade de Ciências Agárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.

Braz J Med Biol Res. 1993 May;26(5):497-507.

We investigated the possible potentiating effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the response of polymorphonuclear neutrophils to carrageenin (150 micrograms, ip) or dextran (100 micrograms, ip) in the peritoneal cavity of male Wistar rats (180-230 g; N = 12 in each group). 2. Chloramphenicol potentiated the cell migration induced by carrageenin (35%) but not that induced by dextran. Previous macrophage depletion in the peritoneal cavity by washing with sterile saline abolished the cell response, whereas a previous thioglycollate-induced increase in macrophage numbers enhanced the potentiating effect (60%). 3. These results suggest that the potentiating effect on polymorphonuclear neutrophil migration induced by chloramphenicol may be related to chemotactic factors released by macrophages.

我们研究了琥珀氯霉素（30毫克/千克，每12小时一次，共4天，腹腔注射）对雄性Wistar大鼠（180 - 230克；每组N = 12）腹腔内多形核中性粒细胞对角叉菜胶（150微克，腹腔注射）或右旋糖酐（100微克，腹腔注射）反应的可能增强作用。2. 氯霉素增强了角叉菜胶诱导的细胞迁移（35%），但未增强右旋糖酐诱导的细胞迁移。先前用无菌盐水冲洗腹腔使巨噬细胞耗竭消除了细胞反应，而先前硫代乙醇酸盐诱导的巨噬细胞数量增加增强了增强作用（60%）。3. 这些结果表明，氯霉素对多形核中性粒细胞迁移的增强作用可能与巨噬细胞释放的趋化因子有关。

Moraes J R, Moraes F R, Bechara G H

Departamento de Patologia Veterinária, Faculdade de Ciências Agárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.

Braz J Med Biol Res. 1993 May;26(5):497-507.

We investigated the possible potentiating effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the response of polymorphonuclear neutrophils to carrageenin (150 micrograms, ip) or dextran (100 micrograms, ip) in the peritoneal cavity of male Wistar rats (180-230 g; N = 12 in each group). 2. Chloramphenicol potentiated the cell migration induced by carrageenin (35%) but not that induced by dextran. Previous macrophage depletion in the peritoneal cavity by washing with sterile saline abolished the cell response, whereas a previous thioglycollate-induced increase in macrophage numbers enhanced the potentiating effect (60%). 3. These results suggest that the potentiating effect on polymorphonuclear neutrophil migration induced by chloramphenicol may be related to chemotactic factors released by macrophages.

我们研究了琥珀氯霉素（30毫克/千克，每12小时一次，共4天，腹腔注射）对雄性Wistar大鼠（180 - 230克；每组N = 12）腹腔内多形核中性粒细胞对角叉菜胶（150微克，腹腔注射）或右旋糖酐（100微克，腹腔注射）反应的可能增强作用。2. 氯霉素增强了角叉菜胶诱导的细胞迁移（35%），但未增强右旋糖酐诱导的细胞迁移。先前用无菌盐水冲洗腹腔使巨噬细胞耗竭消除了细胞反应，而先前硫代乙醇酸盐诱导的巨噬细胞数量增加增强了增强作用（60%）。3. 这些结果表明，氯霉素对多形核中性粒细胞迁移的增强作用可能与巨噬细胞释放的趋化因子有关。