乙醚和制动应激对半肾上腺切除大鼠垂体肾上腺功能的影响。

Ether and immobilization stress effects on pituitary adrenal function in hemidecorticate rats.

作者信息

López-Jiménez M, Valença M M, Moreira A C, Antunes-Rodrigues J

机构信息

Departamento de Fisiologia e Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.

出版信息

Braz J Med Biol Res. 1989;22(6):779-82.

PMID:2620193

Abstract

Hemidecortication (HD) (left cerebral hemisphere) was performed in rats with the aim of analyzing the modulating effect of the cerebral cortex on the hypothalamic-pituitary-adrenal axis. Corticosterone release induced either by ether or immobilization stress was evaluated in control (C) and HD rats. The percentage increase in corticosterone was greater in HD than in C rats after 15 min of ether stress (HD = 142%, C = 50%) and after 60 min of immobilization stress (HD = 197%, C = 126%). An in vitro test showed that the release of ACTH induced by corticotropin releasing hormone (CRH) from hemipituitary fragments from HD rats was not different from that in control rats. These results suggest an inhibitory effect of the cerebral cortex on the hypothalamus which may modulate the secretion of corticotropin releasing peptides.

摘要

为了分析大脑皮层对下丘脑 - 垂体 - 肾上腺轴的调节作用，对大鼠进行了半侧大脑皮质切除术（HD）（左脑半球）。评估了对照（C）组和HD组大鼠在乙醚或固定应激诱导下的皮质酮释放情况。在乙醚应激15分钟后（HD = 142%，C = 50%）和固定应激60分钟后（HD = 197%，C = 126%），HD组大鼠皮质酮的增加百分比高于C组大鼠。体外试验表明，HD组大鼠半垂体碎片中促肾上腺皮质激素释放激素（CRH）诱导的促肾上腺皮质激素（ACTH）释放与对照大鼠无差异。这些结果表明大脑皮层对下丘脑有抑制作用，可能调节促肾上腺皮质激素释放肽的分泌。