杜洛克猪纯种群体中乳头数的全基因组关联QTL定位

Genome-wide association QTL mapping for teat number in a purebred population of Duroc pigs.

作者信息

Arakawa A, Okumura N, Taniguchi M, Hayashi T, Hirose K, Fukawa K, Ito T, Matsumoto T, Uenishi H, Mikawa S

机构信息

Animal Genome Research Unit, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki, 305-8602, Japan.

Animal Research Division, Institute of Japan Association for Techno-innovation in Agriculture, Forestry and Fisheries, 446-1 Ippaizuka, Kamiyokoba, Tsukuba, Ibaraki, 305-0854, Japan.

出版信息

Anim Genet. 2015 Oct;46(5):571-5. doi: 10.1111/age.12331. Epub 2015 Jul 22.

DOI:10.1111/age.12331

PMID:26202474

Abstract

Because of increasing litter size in Western pig breeds, additional teats are desirable to increase the capacity for nursing offspring. We applied genome-wide SNP markers to detect QTL regions that affect teat number in a Duroc population. We phenotyped 1024 animals for total teat number. A total of 36 588 SNPs on autosomes were used in the analysis. The estimated heritability for teat number was 0.34 ± 0.05 on the basis of a genomic relationship matrix constructed from all SNP markers. Using a BayesC method, we identified a total of 18 QTL regions that affected teat number in Duroc pigs; 9 of the 18 regions were newly detected.

摘要

由于西方猪种的窝产仔数不断增加，需要额外的乳头来提高哺育后代的能力。我们应用全基因组SNP标记来检测影响杜洛克猪群乳头数的QTL区域。我们对1024头动物的总乳头数进行了表型分析。分析中使用了常染色体上总共36588个SNP。基于由所有SNP标记构建的基因组关系矩阵，乳头数的估计遗传力为0.34±0.05。使用贝叶斯C方法，我们总共鉴定出18个影响杜洛克猪乳头数的QTL区域；18个区域中有9个是新检测到的。