Baczkó István, Light Peter E
Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Ann N Y Acad Sci. 2015 Aug;1348(1):68-74. doi: 10.1111/nyas.12843. Epub 2015 Jul 23.
Resveratrol is a bioactive polyphenol, found in grapes, red wine, and peanuts, and has recently garnered much media and scientific attention for its diverse beneficial health effects as a nutritional supplement or nutraceutical. Of particular interest are the well-documented cardioprotective effects of resveratrol that are mediated by diverse mechanisms, including its antioxidant and vascular effects. However, it is now becoming clear that resveratrol may also exhibit direct effects on cardiac function and rhythm through modulation of signaling pathways that regulate cardiac remodeling and ion channel activity that controls cardiac excitability. Resveratrol may therefore possess antiarrhythmic properties that contribute to the cardiovascular benefits of resveratrol. Atrial fibrillation (AF) is the most common cardiac arrhythmia, although current therapies are suboptimal. Our laboratory has been studying resveratrol's effects on cardiac ion channels and remodeling pathways, and we initiated a drug development program aimed at generating novel resveratrol derivatives with improved efficacy against AF when compared to currently available therapeutics. This review therefore focuses on the effects of resveratrol and new derivatives on a variety of cardiac ion channels and molecular pathways that contribute to the development and maintenance of atrial fibrillation.
白藜芦醇是一种生物活性多酚，存在于葡萄、红酒和花生中，最近作为一种营养补充剂或营养保健品，因其多样的有益健康功效而备受媒体和科学界关注。白藜芦醇具有充分记录的心脏保护作用，通过多种机制介导，包括其抗氧化和血管作用，这一点尤其令人关注。然而，现在越来越清楚的是，白藜芦醇还可能通过调节参与心脏重塑的信号通路以及控制心脏兴奋性的离子通道活性，对心脏功能和节律产生直接影响。因此，白藜芦醇可能具有抗心律失常特性，这有助于其心血管益处。心房颤动（AF）是最常见的心律失常，尽管目前的治疗方法并不理想。我们实验室一直在研究白藜芦醇对心脏离子通道和重塑途径的影响，并且启动了一个药物开发项目，旨在开发新型白藜芦醇衍生物，与现有治疗方法相比，其对房颤的疗效有所提高。因此，本综述重点关注白藜芦醇及其新衍生物对多种心脏离子通道和分子途径的影响，这些途径参与心房颤动的发生和维持。
