Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Nutrients. 2024 Sep 19;16(18):3168. doi: 10.3390/nu16183168.
The convergence of cardiovascular, kidney, and metabolic disorders at the pathophysiological level has led to the recognition of cardiovascular-kidney-metabolic (CKM) syndrome, which represents a significant global health challenge. Polyphenols, a group of phytochemicals, have demonstrated potential health-promoting effects.
This review highlights the impact of maternal polyphenol supplementation on the CKM health of offspring.
Initially, we summarize the interconnections between polyphenols and each aspect of CKM syndrome. We then discuss in vivo studies that have investigated the use of polyphenols during pregnancy and breastfeeding, focusing on their role in preventing CKM syndrome in offspring. Additionally, we explore the common mechanisms underlying the protective effects of maternal polyphenol supplementation.
Overall, this review underscores the potential of early-life polyphenol interventions in safeguarding against CKM syndrome in offspring. It emphasizes the importance of continued research to advance our understanding and facilitate the clinical translation of these interventions.
心血管、肾脏和代谢紊乱在病理生理水平上的融合导致了心血管-肾脏-代谢（CKM）综合征的认识，这代表了一个重大的全球健康挑战。多酚是一组植物化学物质，已显示出具有促进健康的潜力。
本综述强调了母体多酚补充对后代 CKM 健康的影响。
首先，我们总结了多酚与 CKM 综合征各个方面的相互关系。然后，我们讨论了在怀孕期间和哺乳期使用多酚的体内研究，重点关注它们在预防后代 CKM 综合征中的作用。此外，我们探讨了母体多酚补充的保护作用的常见机制。
总的来说，本综述强调了生命早期多酚干预在预防后代 CKM 综合征中的潜力。它强调了继续研究的重要性，以增进我们对这些干预措施的理解并促进其临床转化。
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