Zhuang G X, Su Y K
Zhonghua Fu Chan Ke Za Zhi. 1989 Sep;24(5):285-7, 317.
The cellular DNA content of paraffin-embedded molar tissue blocks obtained from the first curettage was measured by flow cytometry in 64 cases of hydatidiform mole. Of these 64 cases 32 developed malignant changes and 32 remained persistently benign during a period of follow-up of 0.5 to 7.5 years. The proportion of aneuploid was 59.4% in patients demonstrating malignant changes and 34.4% in those with persistent benign diseases. The difference was statistically significant (P less than 0.05). This preliminary result suggests that DNA aneuploid may be used as a parameter for the prediction of possible malignant changes and selecting of indications for prophylactic chemotherapy.
采用流式细胞术对64例葡萄胎患者首次刮宫获得的石蜡包埋磨牙组织块的细胞DNA含量进行了测定。在0.5至7.5年的随访期内，这64例患者中32例发生恶变，32例持续保持良性。恶变患者的非整倍体比例为59.4%，持续良性疾病患者的非整倍体比例为34.4%。差异具有统计学意义（P<0.05）。这一初步结果表明，DNA非整倍体可作为预测可能恶变及选择预防性化疗指征的一个参数。
