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[甲下恶性黑色素瘤——30年病例回顾]

[Subungual malignant melanoma--30 year review of cases].

作者信息

Shao Y F

机构信息

Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.

出版信息

Zhonghua Zhong Liu Za Zhi. 1989 Sep;11(5):380-2.

PMID:2620637
Abstract

Twenty-five patients with subungual malignant melanoma confirmed by pathology from 1958 to 1987 were reported. There were 19 males and 6 females. 76% of the lesions occurred on the finger and 24% on the foot. The most common site was the thumb or great toe. 16/25 of the patients had history of subungual pigmented streaks. As trauma at the lesion site might initiate subungual melanoma (28%), doctors should pay close attention to the subungual black pigmented streaks or a mass below the nail with a history of trauma in order to avoid mis-diagnosis. In these 25 patients, the diagnosis was delayed in 19, and 10 of them already had regional lymph node metastasis. Surgical treatment still played a major role for subungual melanoma. According to the clinical staging, various degrees of amputation at different levels and regional lymph node dissection were recommended. The 5-year survival rate in this group was 28% (7/25).

摘要

报告了1958年至1987年经病理确诊的25例甲下恶性黑色素瘤患者。其中男性19例,女性6例。76%的病变发生在手指,24%发生在足部。最常见的部位是拇指或拇趾。25例患者中有16例有甲下色素沉着条纹病史。由于病变部位的创伤可能引发甲下黑色素瘤(28%),医生应密切关注有创伤史的甲下黑色色素沉着条纹或指甲下的肿物,以避免误诊。在这25例患者中,19例诊断延迟,其中10例已有区域淋巴结转移。手术治疗仍然是甲下黑色素瘤的主要治疗方法。根据临床分期,建议进行不同程度的不同平面截肢及区域淋巴结清扫。该组患者的5年生存率为28%(7/25)。

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