Hwang Kristy S, Lazaris Andreas S, Eastman Jennifer A, Teng Edmond, Thompson Paul M, Gylys Karen H, Cole Gregory M, Apostolova Liana G
Oakland University William Beaumont School of Medicine, Rochester Hills, MI USA.
University of California Berkeley, Berkeley, CA, USA.
Alzheimers Dement (Amst). 2015 Jun 1;1(2):187-193. doi: 10.1016/j.dadm.2015.01.005.
Brain-derived neurotrophic factor (BDNF) plays an important role in Alzheimer's disease (AD) and other neurodegenerative disorders. BDNF function is adversely affected by amyloid beta (Aβ) in AD. BDNF levels in brain and peripheral tissues are lower in patients with AD and MCI, than in controls. Here we examined the association between plasma levels of BDNF and amyloid deposition in the brain measured with Pittsburgh Compound B (PiB).
Our dataset consisted of 18 AD, 56 mild cognitive impairment (MCI) and 3 normal control (NC) Alzheimer's Disease Neuroimaging Initiative-1 (ADNI1) subjects with available [C] PiB and peripheral blood protein data. MRI-coregistered PET data was smoothed with a 15 mm kernel and mapped onto 3D hemispheric models using the warping deformations computed in cortical pattern matching of the associated MRI scans. We applied linear regression to examine in 3D the associations between BDNF and PiB SUVR, while adjusting for age and sex. We used permutation statistics thresholded at p<0.01 for multiple comparisons correction.
Plasma BDNF levels showed significant negative associations with left greater than right amyloid burden in the lateral temporal, inferior parietal, inferior frontal, anterior and posterior cingulate, and orbitofrontal regions (left p=0.03).
As hypothesized, lower plasma levels of BDNF were significantly associated with widespread brain amyloidosis.
脑源性神经营养因子（BDNF）在阿尔茨海默病（AD）及其他神经退行性疾病中发挥着重要作用。在AD中，BDNF功能受到β淀粉样蛋白（Aβ）的不利影响。AD和轻度认知障碍（MCI）患者脑和外周组织中的BDNF水平低于对照组。在此，我们研究了用匹兹堡化合物B（PiB）测量的血浆BDNF水平与脑内淀粉样蛋白沉积之间的关联。
我们的数据集包括18名AD患者、56名轻度认知障碍（MCI）患者和3名正常对照（NC）的阿尔茨海默病神经影像倡议-1（ADNI1）受试者，他们有可用的[C]PiB和外周血蛋白数据。MRI配准的PET数据用15毫米核进行平滑处理，并使用在相关MRI扫描的皮质模式匹配中计算出的扭曲变形映射到3D半球模型上。我们应用线性回归在3D中检验BDNF与PiB标准化摄取值比（SUVR）之间的关联，同时对年龄和性别进行校正。我们使用排列统计，以p<0.01为阈值进行多重比较校正。
血浆BDNF水平与左侧颞叶外侧、顶叶下部、额叶下部、前扣带回和后扣带回以及眶额区域的淀粉样蛋白负担呈显著负相关（左侧p=0.03），左侧大于右侧。
正如所假设的，较低的血浆BDNF水平与广泛的脑淀粉样变性显著相关。
