综合干预对阿尔茨海默病患者血浆脑源性神经营养因子的影响
Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease.
作者信息
Balietti Marta, Giuli Cinzia, Fattoretti Patrizia, Fabbietti Paolo, Papa Roberta, Postacchini Demetrio, Conti Fiorenzo
机构信息
Center for Neurobiology of Aging, INRCA, Ancona, Italy.
Geriatrics Operative Unit, INRCA, Fermo, Italy.
出版信息
J Alzheimers Dis. 2017;57(1):37-43. doi: 10.3233/JAD-161168.
A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients' cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.
通过在综合干预（CI）前、干预刚结束后（随访1，FU1）、干预后6个月（随访2，FU2）和24个月（随访3，FU3）测量血浆脑源性神经营养因子（pBDNF）和阿尔茨海默病评定量表认知部分得分（ADAS-Cog得分），对阿尔茨海默病患者的综合干预进行了评估。中度阿尔茨海默病患者（而非轻度阿尔茨海默病患者）的基线pBDNF高于健康对照。在随访1时，pBDNF和ADAS-Cog得分显著下降。在随访2和随访3时，患者的认知状态恶化，且与基线相比pBDNF进一步升高，这表明CI中断可能是一个阻碍恢复内稳态的应激事件。CI产生了积极的短期效果，但关于长期后果还需要更多信息。
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