对氨基苯甲酸酯类减少紫外线对人皮肤DNA的损伤
Decrease of ultraviolet-induced DNA injury in human skin by p-aminobenzoic acid esters.
作者信息
De Rijcke S, Heenen M
机构信息
Department of Dermatology, Hospital Erasme, Free University of Brussels, Belgium.
出版信息
Dermatologica. 1989;179(4):196-9. doi: 10.1159/000248359.
PMID:2620751
Abstract
The effect of a sunscreen containing a p-aminobenzoic acid (PABA) ester on ultraviolet-induced DNA injury was assessed on human epidermal cells by the measure of unscheduled DNA synthesis intensity. Our results show that DNA repair was reduced by approximately 50%. Therefore, sunscreens based on PABA esters might be expected to reduce photocarcinogenesis.
摘要
通过测量非程序性DNA合成强度，评估了一种含有对氨基苯甲酸（PABA）酯的防晒霜对紫外线诱导的人类表皮细胞DNA损伤的影响。我们的结果表明，DNA修复减少了约50%。因此，可以预期基于PABA酯的防晒霜能减少光致癌作用。
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