巨大儿在幼儿期患龋齿的风险增加：来自队列研究——日本冲绳儿童健康研究的结果
Macrosomic Neonates Carry Increased Risk of Dental Caries in Early Childhood: Findings from a Cohort Study, the Okinawa Child Health Study, Japan.
作者信息
Yokomichi Hiroshi, Tanaka Taichiro, Suzuki Kohta, Akiyama Tomoki, Yamagata Zentaro
机构信息
Department of Health Sciences, Division of Medicine, Graduate School Department of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan.
Department of Social Medicine, Faculty of Medicine, Toho University, 5-21-16, Ohmorinisi, Ohta Ward, Tokyo, Japan.
出版信息
PLoS One. 2015 Jul 24;10(7):e0133872. doi: 10.1371/journal.pone.0133872. eCollection 2015.
BACKGROUND
Although many studies have discussed health risks in neonates with a low birth weight, few studies have focused on the risks in neonates with a high birth weight. The objective of this study was to determine whether differences in the incidence of dental caries in early childhood are associated with birth weight status.
METHODS
A total of 117,175 children born in Okinawa Prefecture, Japan from 1997 to 2007 were included in this study. Medical professionals collected information about birth records, growth and development, parental child-rearing practices and dental health at 3 months, 18 months and 3 years of age. The risk of dental caries among neonates with macrosomia (birth weight ≥4000 g) was compared with that among neonates with normal weight (2500-3999 g). Sensitivity analyses included 'large for gestational age' (LGA, birth weight above the 90th percentile for gestational age), which was relative to 'appropriate for gestational age' (birth weight between 10th and 90th percentiles). Relative risks and relative risk increases were estimated by multivariate Poisson regression.
RESULTS
At 3 years of age, the relative risk increases for dental caries after adjusting for confounding factors were 19% [95% confidence interval (CI), 11%-28%, P < 0.001] for macrosomic neonates and 12% (95% CI, 9%-16%, P < 0.001) for LGA neonates.
CONCLUSION
Macrosomia and LGA were associated with an increased risk of dental caries in early childhood. Particular attention should be paid to abnormally large neonates.
背景
尽管许多研究探讨了低出生体重新生儿的健康风险，但很少有研究关注高出生体重新生儿的风险。本研究的目的是确定幼儿期龋齿发病率的差异是否与出生体重状况有关。
方法
本研究纳入了1997年至2007年在日本冲绳县出生的117,175名儿童。医学专业人员收集了有关出生记录、生长发育、父母育儿方式以及3个月、18个月和3岁时牙齿健康状况的信息。将巨大儿（出生体重≥4000克）新生儿的龋齿风险与正常体重（2500 - 3999克）新生儿的龋齿风险进行比较。敏感性分析包括“大于胎龄儿”（LGA，出生体重高于胎龄的第90百分位数），并与“适于胎龄儿”（出生体重在第10至90百分位数之间）进行对比。通过多变量泊松回归估计相对风险和相对风险增加率。
结果
在3岁时，校正混杂因素后，巨大儿新生儿患龋齿的相对风险增加率为19%[95%置信区间（CI），11% - 28%，P < 0.001]，LGA新生儿为12%（95%CI，9% - 16%，P < 0.001）。
结论
巨大儿和LGA与幼儿期患龋齿风险增加有关。应特别关注异常大的新生儿。
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