黑腹果蝇中的组蛋白赖氨酸去甲基化酶
Histone lysine demethylases in Drosophila melanogaster.
作者信息
Holowatyj Andreana, Yang Zeng-Quan, Pile Lori A
机构信息
a Department of Oncology ; Wayne State University School of Medicine ; Detroit , MI USA.
出版信息
Fly (Austin). 2015;9(1):36-44. doi: 10.1080/19336934.2015.1074787.
Abstract
Epigenetic regulation of chromatin structure is a fundamental process for eukaryotes. Regulators include DNA methylation, microRNAs and chromatin modifications. Within the chromatin modifiers, one class of enzymes that can functionally bind and modify chromatin, through the removal of methyl marks, is the histone lysine demethylases. Here, we summarize the current findings of the 13 known histone lysine demethylases in Drosophila melanogaster, and discuss the critical role of these histone-modifying enzymes in the maintenance of genomic functions. Additionally, as histone demethylase dysregulation has been identified in cancer, we discuss the advantages for using Drosophila as a model system to study tumorigenesis.
摘要
染色质结构的表观遗传调控是真核生物的一个基本过程。调控因子包括DNA甲基化、微小RNA和染色质修饰。在染色质修饰因子中，一类能够通过去除甲基标记在功能上结合并修饰染色质的酶是组蛋白赖氨酸去甲基化酶。在这里，我们总结了目前在黑腹果蝇中已知的13种组蛋白赖氨酸去甲基化酶的研究结果，并讨论了这些组蛋白修饰酶在维持基因组功能中的关键作用。此外，由于在癌症中已发现组蛋白去甲基化酶失调，我们讨论了使用果蝇作为研究肿瘤发生的模型系统的优势。
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