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治疗孤立肾鹿角形结石的最佳微创经皮肾镜取石术策略

The optimal minimally invasive percutaneous nephrolithotomy strategy for the treatment of staghorn stones in a solitary kidney.

作者信息

Liu Chenli, Cui Zelin, Zeng Guohua, Wan Shaw P, Li Jiasheng, Zhu Wei, Zeng Tao, Liu Yang

机构信息

Department of Urology, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

出版信息

Urolithiasis. 2016 Apr;44(2):149-54. doi: 10.1007/s00240-015-0803-3. Epub 2015 Jul 25.

Abstract

The objective of the study was to analyze the treatment outcomes for staghorn stones in patients with solitary kidney using either the single-tract or the multi-tract minimally invasive percutaneous nephrolithotomy (MPCNL). We retrospectively reviewed 105 patients who underwent MPCNL for staghorn calculi in solitary kidney from 2012 to 2014. The patients who underwent the single-tract approach (71 patients) were assigned to Group 1. The 34 patients who underwent the multi-tract approach (34 patients) were assigned to Group 2. We recorded and compared the patient's demographics, intraoperative parameters, and post-operative outcomes. We also analyzed any complications as a result of the particular procedure, as well as any resulting stone-free rates (SFRs). The mean number of access tracts was 2.38 ± 0.70 (range 2-4) for Group 2. The mean operative time was longer for Group 2, p = 0.01. The initial SFR was 52.1% for Group 1 and 47.1% for Group 2 after the one-session procedure, p = 0.63.The final SFR improved to 83.1 and 79.4% for both groups following auxiliary treatment, p = 0.65. The mean hemoglobin drop was higher in Group 2 as compared to Group 1, p < 0.01. There was no significant difference in the change of mean serum creatinine in either group. There were fewer overall complications in Group 1 than in Group 2 (23.9 vs. 44.1%). Almost half of the patients who underwent multi-tract MPCNL required an additional procedure to achieve satisfactory stone clearance. The results showed that single-tract MPCNL might be a better treatment option for staghorn stones in a solitary kidney with the same therapeutic outcome, but with less complications.

摘要

本研究的目的是分析采用单通道或多通道微创经皮肾镜取石术(MPCNL)治疗孤立肾鹿角形结石患者的治疗效果。我们回顾性分析了2012年至2014年期间因孤立肾鹿角形结石接受MPCNL治疗的105例患者。采用单通道入路的71例患者被分配到第1组。采用多通道入路的34例患者被分配到第2组。我们记录并比较了患者的人口统计学资料、术中参数和术后结果。我们还分析了特定手术导致的任何并发症以及由此产生的无石率(SFR)。第2组的平均通道数为2.38±0.70(范围2 - 4)。第2组的平均手术时间更长,p = 0.01。第1组单次手术后的初始无石率为52.1%,第2组为47.1%,p = 0.63。辅助治疗后两组的最终无石率分别提高到83.1%和79.4%,p = 0.65。第2组的平均血红蛋白下降幅度高于第1组,p < 0.01。两组患者平均血清肌酐变化无显著差异。第1组的总体并发症少于第2组(23.9%对44.1%)。几乎一半接受多通道MPCNL的患者需要额外的手术才能达到满意的结石清除效果。结果表明,单通道MPCNL对于孤立肾鹿角形结石可能是更好的治疗选择,具有相同的治疗效果,但并发症更少。

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