Lepeltier Elise, Bourgaux Claudie, Amenitsch Heinz, Rosilio Véronique, Lepetre-Mouelhi Sinda, Zouhiri Fatima, Desmaële Didier, Couvreur Patrick
Institut Galien Paris-Sud - UMR CNRS 8612, Faculté de Pharmacie, Université Paris-Sud XI, 92296 Châtenay-Malabry Cedex, France.
Institut Galien Paris-Sud - UMR CNRS 8612, Faculté de Pharmacie, Université Paris-Sud XI, 92296 Châtenay-Malabry Cedex, France.
Eur J Pharm Biopharm. 2015 Oct;96:89-95. doi: 10.1016/j.ejpb.2015.07.004. Epub 2015 Jul 22.
Hydrophobic organic compounds dissolved in a polar solvent can self-assemble into nanoparticles (NPs) upon nanoprecipitation into water. In the present study, we have investigated the structure of squalenacetyl-adenosine (SQAc-Ad) nanoparticles which were previously found to exhibit impressive neuroprotective activity. When obtained by nanoprecipitation of a SQAc-Ad ethanolic solution into water, two different supramolecular organizations of SQAc-Ad NPs were evidenced, depending on the water-to-ethanol volume ratio. It has been shown that a fraction of the solvent remained associated with the NPs, despite prolonged evaporation under reduced pressure after nanoprecipitation, and that this residual solvent dramatically affected their structure. This study points to the importance of being in the "Ouzo" region to minimize the amount and effect of residual solvent and to control the structure of NPs.
溶解在极性溶剂中的疏水性有机化合物在纳米沉淀到水中时可自组装成纳米颗粒（NP）。在本研究中，我们研究了角鲨烯乙酰腺苷（SQAc-Ad）纳米颗粒的结构，该纳米颗粒先前被发现具有令人印象深刻的神经保护活性。当通过将SQAc-Ad乙醇溶液纳米沉淀到水中获得时，根据水与乙醇的体积比，可证明SQAc-Ad NP存在两种不同的超分子组织。结果表明，尽管纳米沉淀后在减压下长时间蒸发，仍有一部分溶剂与NP结合，并且这种残留溶剂显著影响了它们的结构。这项研究指出了处于“茴香酒”区域对于最小化残留溶剂的量和影响以及控制NP结构的重要性。
