UMR CNRS 8612, Institut Galien Paris-Sud, Université Paris-Sud, France.
Adv Drug Deliv Rev. 2014 May;71:86-97. doi: 10.1016/j.addr.2013.12.009. Epub 2013 Dec 30.
Biodegradable nanocarriers such as lipid- or polymer-based nanoparticles can be designed to improve the efficacy and reduce the toxic side effects of drugs. Under appropriate conditions, nanoprecipitation of a hydrophobic compound solution in a non-solvent can generate a dispersion of nanoparticles with a narrow distribution of sizes without the use of surfactant ("Ouzo" effect). The aim of this review is to present the main parameters controlling the nucleation and growth of aggregates in a supersaturated solution and the characteristics of the obtained nanoparticles. The importance of the kinetics of mixing of the solution containing the hydrophobic compound and the non-solvent is highlighted. Illustrative examples of polymeric nanoparticles for drug delivery or terpenoid-based nanoprodrugs obtained by nanoprecipitation are reported.
可生物降解的纳米载体，如基于脂质或聚合物的纳米颗粒，可以设计用于提高药物的疗效和降低其毒副作用。在适当的条件下，疏水性化合物溶液在非溶剂中的胶凝可以在不使用表面活性剂的情况下生成具有窄粒径分布的纳米颗粒分散体（“Ouzo”效应）。本综述的目的是介绍控制过饱和溶液中聚集体成核和生长的主要参数以及所得到的纳米颗粒的特性。强调了含有疏水性化合物的溶液与非溶剂混合的动力学的重要性。报道了通过胶凝法获得的用于药物传递的聚合物纳米颗粒和基于萜烯的纳米前药的实例。
