Aarhus University, Faculty of Science and Technology, Department of Bioscience, Arctic Research Centre, Frederiksborgvej, 399, P.O. Box 358, DK-4000 Roskilde, Denmark.
Aarhus University, Faculty of Science and Technology, Department of Bioscience, Arctic Research Centre, Frederiksborgvej, 399, P.O. Box 358, DK-4000 Roskilde, Denmark.
Environ Res. 2015 Oct;142:380-6. doi: 10.1016/j.envres.2015.06.034. Epub 2015 Jul 25.
We used PBPK (physiologically-based pharmacokinetic) modelling to investigate distribution, bioaccumulation and excretion of the seven POPs (persistent organic pollutants) CB-99, CB-153, HCB, oxychlordane, p,p'-DDE, BDE-47 and BDE-99 in 4 adult captive Greenland sledge dog (Canis familiaris) bitches fed minke whale (Balaenoptera acuterostrata) blubber for 500-635 days. The PBPK modelled POP concentrations in adipose tissue, liver, kidney and plasma were mostly within a factor 2 of actual measured tissue levels even for those at the lower concentration end. The excretion route for oxychlordane and CB-153 was modelled to be via faeces while lung alveolar excretion dominated for BDE-47, BDE-99, HCB, p,p'-DDE and CB-99. Furthermore the model suggested the retained mass of POPs after 500 and 635 days of exposure, respectively, to be relatively low despite these POPs being highly recalcitrant. The retention increased in the following order (% of total intake); p,p'-DDE (1%)<BDE-47 (6%)<CB-99 (14%)<HCB (16%)<CB-153 (18%)<BDE-99 (26%)<oxychlordane (34%). Overall; these results indicate that PBPK modelling may be a strong tool in risk assessment of POPs in arctic mammals.
我们使用基于生理的药代动力学（PBPK）模型来研究七种持久性有机污染物（POPs）CB-99、CB-153、HCB、氧氯丹、p,p'-DDE、BDE-47 和 BDE-99 在 4 只被喂食小须鲸（Balaenoptera acuterostrata）鲸脂 500-635 天的圈养格陵兰雪橇犬（Canis familiaris）母犬体内的分布、生物蓄积和排泄情况。即使对于浓度较低的组织，PBPK 模型模拟的 POP 在脂肪组织、肝脏、肾脏和血浆中的浓度大多在实际测量组织水平的 2 倍以内。氧氯丹和 CB-153 的排泄途径被模拟为通过粪便，而 BDE-47、BDE-99、HCB、p,p'-DDE 和 CB-99 的主要排泄途径则是通过肺部肺泡。此外，该模型表明，尽管这些 POP 高度持久，但在暴露于 500 和 635 天后，POP 的保留量相对较低。保留量的增加顺序为（占总摄入量的百分比）；p,p'-DDE（1%）<BDE-47（6%）<CB-99（14%）<HCB（16%）<CB-153（18%）<BDE-99（26%）<氧氯丹（34%）。总的来说，这些结果表明，PBPK 模型可能是评估北极哺乳动物中 POP 风险的有力工具。
