Dzikowska Agnieszka, Grzelak Anna, Gawlik Joanna, Szewczyk Edyta, Mrozek Paweł, Borsuk Piotr, Koper Michał, Empel Joanna, Szczęsny Paweł, Piłsyk Sebastian, Pękala Małgorzata, Weglenski Piotr
Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul. Pawińskiego 5A, 02-106 Warsaw, Poland; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawińskiego 5A, 02-106 Warsaw, Poland.
Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul. Pawińskiego 5A, 02-106 Warsaw, Poland.
Gene. 2015 Dec 1;573(2):310-20. doi: 10.1016/j.gene.2015.07.066. Epub 2015 Jul 23.
The kaeA(KAE1) (suDpro) gene, which was identified in Aspergillus nidulans as a suppressor of proline auxotrophic mutations, encodes the orthologue of Saccharomyces cerevisiae Kae1p, a member of the evolutionarily conserved KEOPS/EKC (Kinase, Endopeptidase and Other Proteins of Small size/Endopeptidase-like and Kinase associated to transcribed Chromatin) complex. In yeast, this complex has been shown to be involved in tRNA modification, transcription, and genome maintenance. In A. nidulans, mutations in kaeA result in several phenotypic effects, the derepression of arginine catabolism genes, and changes in the expression levels of several others, including genes involved in amino acid and siderophore metabolism, sulfate transport, carbon/energy metabolism, translation, and transcription regulation, such as rcoA(TUP1), which encodes the global transcriptional corepressor.
在构巢曲霉中被鉴定为脯氨酸营养缺陷型突变抑制子的kaeA（KAE1）（suDpro）基因，编码酿酒酵母Kae1p的直系同源物，Kae1p是进化上保守的KEOPS/EKC（激酶、内肽酶和其他小尺寸蛋白质/与转录染色质相关的类内肽酶和激酶）复合体的成员。在酵母中，该复合体已被证明参与tRNA修饰、转录和基因组维持。在构巢曲霉中，kaeA的突变会导致多种表型效应，精氨酸分解代谢基因的去阻遏，以及其他几个基因表达水平的变化，包括参与氨基酸和铁载体代谢、硫酸盐转运、碳/能量代谢、翻译和转录调控的基因，如编码全局转录共抑制因子的rcoA（TUP1）。
