Adjeroud Najia, Besnard Jérémy, El Massioui Nicole, Verny Christophe, Prudean Adriana, Scherer Clarisse, Gohier Bénédicte, Bonneau Dominique, Allain Philippe
Paris-Saclay Institute of Neuroscience, UMR 9197, Deparment cognition & Behavior, Université Paris-Sud, Orsay, F-91405, Centre National de Référence pour les Maladies Neurogénétiques de l'Adulte, Département de Neurologie, Centre Hospitalier Universitaire d'Angers, Angers France, and.
LUNAM Université, Université d'Angers, Laboratoire de Psychologie des Pays de la Loire (EA 4638), Angers, France.
Soc Cogn Affect Neurosci. 2016 Jan;11(1):89-99. doi: 10.1093/scan/nsv093. Epub 2015 Jul 25.
We investigated cognitive and affective Theory of Mind (ToM) and empathy in patients with premanifest and manifest Huntington's disease (HD). The relationship between ToM performance and executive skills was also examined. Sixteen preclinical and 23 clinical HD patients, and 39 healthy subjects divided into 2 control groups were given a French adaptation of the Yoni test (Shamay-Tsoory, S.G., Aharon-Peretz, J. (2007). Dissociable prefrontal networks for cognitive and affective theory of mind: a lesion study. Neuropsychologia, 45(3), 3054-67) that examines first- and second-order cognitive and affective ToM processing in separate conditions with a physical control condition. Participants were also given questionnaires of empathy and cognitive tests which mainly assessed executive functions (inhibition and mental flexibility). Clinical HD patients made significantly more errors than their controls in the first- and second-order cognitive and affective ToM conditions of the Yoni task, but exhibited no empathy deficits. However, there was no evidence that ToM impairment was related to cognitive deficits in these patients. Preclinical HD patients were unimpaired in ToM tasks and empathy measures compared with their controls. Our results are consistent with the idea that impaired affective and cognitive mentalizing emerges with the clinical manifestation of HD, but is not necessarily part of the preclinical stage. Furthermore, these impairments appear independent of executive dysfunction and empathy.
我们研究了前驱期和显性亨廷顿舞蹈症（HD）患者的认知和情感心理理论（ToM）及共情能力。同时也考察了ToM表现与执行技能之间的关系。16名临床前期和23名临床HD患者，以及分为2个对照组的39名健康受试者接受了Yoni测试的法语改编版（Shamay-Tsoory, S.G., Aharon-Peretz, J.（2007年）。认知和情感心理理论的可分离前额叶网络：一项病变研究。《神经心理学》，45(3)，3054 - 67），该测试在单独条件下以及一个物理对照条件下考察一阶和二阶认知及情感ToM加工。参与者还接受了共情问卷和主要评估执行功能（抑制和心理灵活性）的认知测试。临床HD患者在Yoni任务的一阶和二阶认知及情感ToM条件下比其对照组犯的错误显著更多，但未表现出共情缺陷。然而，没有证据表明这些患者的ToM损害与认知缺陷有关。与对照组相比，临床前期HD患者在ToM任务和共情测量方面未受损。我们的结果与以下观点一致，即情感和认知心理化受损随着HD的临床表现而出现，但不一定是临床前期阶段的一部分。此外，这些损害似乎独立于执行功能障碍和共情。
