Zhang Xiaojing, Lv Zunfu, Yu Hua, Wang Fangfang, Zhu Jianqing
Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, PR China.
Department of Agriculture and Food Science, Zhejiang Agriculture and Forest University, Lin'an, 311300, PR China.
Biomed Pharmacother. 2015 Jul;73:58-64. doi: 10.1016/j.biopha.2015.06.002. Epub 2015 Jun 15.
Human leukocyte antigens (HLA) alleles may affect the development of cervical cancer through immunologic control of human papillomavirus (HPV). The association between HLA-DQB1 alleles and risk of cervical cancer has been extensively studied, but the results obtained remain inconsistent. To explore a more extensive role of HLA-DQB1 alleles on cervical cancer risk, we carried out a meta-analysis including 4862 cases and 8988 controls from 22 published studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. The overall results suggested that HLA-DQB1*02 (OR=0.91, 95% CI=0.82-0.99), *03 (OR=0.85, 95% CI=0.74-0.97) and 0603 (OR=0.62, 95% CI=0.53-0.72) had a significantly association with decreased cervical cancer risk. In contrast, DQB105 (OR=1.18, 95% CI=1.01-1.38), *0301 (OR=1.14, 95% CI=1.06-1.23) and *0402 (OR=1.31, 95% CI=1.04-1.64) conferred a significantly higher risk to cervical cancer. Moreover, a significantly association with increased or decreased cervical cancer risk was found among Europeans and Asians after stratification of the HLA-DQB1 alleles by ethnicity. These findings supported that the HLA-DQB1 alleles may contribute to genetic susceptibility of cervical cancer. Further studies with a greater number of cases are expected to confirm our results.
人类白细胞抗原（HLA）等位基因可能通过对人乳头瘤病毒（HPV）的免疫控制来影响宫颈癌的发展。HLA - DQB1等位基因与宫颈癌风险之间的关联已得到广泛研究，但所得结果仍不一致。为了探究HLA - DQB1等位基因在宫颈癌风险方面更广泛的作用，我们进行了一项荟萃分析，纳入了来自22项已发表研究的4862例病例和8988例对照。采用比值比（OR）和95%置信区间（CI）来评估关联强度。总体结果表明，HLA - DQB102（OR = 0.91，95% CI = 0.82 - 0.99）、03（OR = 0.85，95% CI = 0.74 - 0.97）和0603（OR = 0.62，95% CI = 0.53 - 0.72）与宫颈癌风险降低显著相关。相比之下，DQB105（OR = 1.18，95% CI = 1.01 - 1.38）、0301（OR = 1.14，95% CI = 1.06 - 1.23）和0402（OR = 1.31，95% CI = 1.04 - 1.64）使患宫颈癌的风险显著更高。此外，按种族对HLA - DQB1等位基因进行分层后，在欧洲人和亚洲人中发现了与宫颈癌风险增加或降低显著相关的情况。这些发现支持HLA - DQB1等位基因可能与宫颈癌的遗传易感性有关。预计更多病例的进一步研究将证实我们的结果。
