HLA-DQB1基因多态性与类风湿关节炎的关联：一项荟萃分析。

Association of HLA-DQB1 polymorphisms with rheumatoid arthritis: a meta-analysis.

作者信息

Wu Jun, Li Jun, Li Si, Zhang Tian-Ping, Li Lian-Ju, Lv Tian-Tian, Pan Hai-Feng, Ye Dong-Qing

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.

The Key Laboratory of Major Autoimmune Disease, Anhui Province, Anhui Medical University, Hefei, China.

出版信息

Postgrad Med J. 2017 Oct;93(1104):618-625. doi: 10.1136/postgradmedj-2016-134724. Epub 2017 Apr 28.

DOI:10.1136/postgradmedj-2016-134724

PMID:28455285

Abstract

AIM

Studies investigating the association between HLA-DQB1 alleles and rheumatoid arthritis (RA) have reported conflicting results. The purpose of this study was to evaluate whether DQB1 alleles confer susceptibility to RA.

DESIGN

A comprehensive literature search up to May 2016 was conducted to identify case-control studies on the association of HLA-DQB1 alleles with RA. Pooled ORs with 95% CIs were used to assess the strength of association.

SETTING

The literature indicates that HLA-DQB1 is associated with susceptibility to RA.

MAIN OUTCOME MEASURES

Frequencies of HLA-DQB1 alleles and phenotype in RA patients and healthy controls.

RESULTS

Fifteen studies with 1250 cases and 1621 controls were included in this meta-analysis. DQB1 alleles were associated with RA susceptibility. The frequencies of DQB106 were lower in RA (p-value for comparability=0.007, OR 0.726,95% CI 0.576 to 0.916; p0.004, OR 0.611,95% CI 0.438 to 0.852). The frequencies of DQB102 were lower in RA (p0.044, OR 0.731,95% CI 0.597 to 0.895). A higher frequency of DQB1*04 was observed in RA (p0.023, OR 1.604,95% CI 1.067 to 2.410).

CONCLUSIONS

This meta-analysis demonstrates that DQB102 and DQB106 may be negatively associated with RA. Conversely, DQB1*04 may confer susceptibility to RA.

摘要

目的

关于研究人类白细胞抗原-DQB1（HLA-DQB1）等位基因与类风湿性关节炎（RA）之间关联的研究报告了相互矛盾的结果。本研究的目的是评估DQB1等位基因是否会使人易患RA。

设计

进行了一项截至2016年5月的全面文献检索，以确定关于HLA-DQB1等位基因与RA关联的病例对照研究。采用合并比值比（OR）及95%可信区间（CI）来评估关联强度。

背景

文献表明HLA-DQB1与RA易感性相关。

主要观察指标

RA患者和健康对照中HLA-DQB1等位基因及表型的频率。

结果

本荟萃分析纳入了15项研究，共1250例病例和1621例对照。DQB1等位基因与RA易感性相关。RA患者中DQB106的频率较低（可比性p值 = 0.007，OR 0.726，95%CI 0.576至0.916；p = 0.004，OR 0.611，95%CI 0.438至0.852）。RA患者中DQB102的频率较低（p = 0.044，OR 0.731，95%CI 0.597至0.895）。在RA患者中观察到DQB1*04的频率较高（p = 0.023，OR 1.604，95%CI 1.067至2.410）。