Stevens Jonathan R, Justin Coffey M, Fojtik Megan, Kurtz Kristina, Stern Theodore A
Outpatient Services, Menninger Clinic, Houston, TX; Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX.
Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX; Neurostimulation and Clinical Informatics Menninger Clinic, Houston, TX.
Psychosomatics. 2015 Sep-Oct;56(5):423-44. doi: 10.1016/j.psym.2015.03.007. Epub 2015 Apr 1.
Numerous currently available medications that act in the central nervous system can be delivered transdermally. Such medications include cholinesterase inhibitors for dementia, methylphenidate (MPH) for attention-deficit hyperactivity disorder, monoamine oxidase inhibitors (MAOIs) for depression, dopamine agonists for Parkinson disease and restless leg syndrome, and clonidine for attention-deficit hyperactivity disorder and impulse-control disorders.
This article aims to review the literature related to transdermal delivery systems from the perspective of clinical practice and research related to their use in the treatment of psychiatric conditions.
Most of the currently available transdermal systems have psychotropic properties or utility in the behavioral health arena and, therefore, are of clinical relevance to consultation-liaison psychiatrists or practitioners of psychosomatic medicine. We discuss their efficacy and safety profiles. We provide a table of these agents and their uses.
Transdermal delivery (i.e., patches) for medicines with psychotropic properties allows mental health providers to customize therapy for patients by altering the duration of therapy, minimizing first-pass metabolism and the potential for drug-drug interactions, and decreasing the risk for gastrointestinal irritation.
目前有许多作用于中枢神经系统的药物可经皮给药。这类药物包括用于治疗痴呆的胆碱酯酶抑制剂、用于治疗注意力缺陷多动障碍的哌甲酯（MPH）、用于治疗抑郁症的单胺氧化酶抑制剂（MAOIs）、用于治疗帕金森病和不宁腿综合征的多巴胺激动剂，以及用于治疗注意力缺陷多动障碍和冲动控制障碍的可乐定。
本文旨在从临床实践以及其在精神疾病治疗中的应用研究角度，对经皮给药系统的相关文献进行综述。
目前大多数可用的经皮给药系统在行为健康领域具有精神otropic特性或用途，因此，与会诊联络精神科医生或身心医学从业者具有临床相关性。我们讨论了它们的疗效和安全性概况。我们提供了这些药物及其用途的表格。
具有精神otropic特性的药物经皮给药（即贴片）使心理健康提供者能够通过改变治疗持续时间、最小化首过代谢和药物相互作用的可能性以及降低胃肠道刺激风险，为患者定制治疗方案。
