从粘细菌 Cystobacter sp. MCy9104 中分离得到的囊色酮，一种含有罕见色酮的聚酮化合物。

Cystochromones, Unusual Chromone-Containing Polyketides from the Myxobacterium Cystobacter sp. MCy9104.

机构信息

Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Pharmaceutical Biotechnology, Saarland University , Campus C2 3, 66123 Saarbrücken, Germany.

German Center for Infection Research (DZIF) , Partner site Hannover-Braunschweig 38124 Hannover-Braunschweig, Germany.

出版信息

J Nat Prod. 2015 Aug 28;78(8):2023-8. doi: 10.1021/acs.jnatprod.5b00343. Epub 2015 Jul 27.

DOI:10.1021/acs.jnatprod.5b00343

PMID:26214047

Abstract

Seven new chromone-containing polyketides, termed cystochromones A-G, were isolated from the myxobacterial strain Cystobacter sp. MCy9104. Their structures were elucidated using comprehensive NMR spectroscopy and HR-MS/MS. Cystochromones bear a pentadecyl moiety unusually attached at C-5 of the chromone ring. Moreover, isotope-labeled substrate feeding experiments and NMR analysis suggested a hybrid iso-fatty acid and polyketide synthase biosynthetic pathway for these secondary metabolites.

摘要

从粘细菌菌株 Cystobacter sp. MCy9104 中分离得到了七种新的含色酮的聚酮化合物，分别命名为 cystochromones A-G。通过全面的 NMR 光谱和高分辨 MS/MS 确定了它们的结构。cystochromones 具有一个不寻常的十五烷基部分，连接在色酮环的 C-5 位上。此外，同位素标记的底物喂养实验和 NMR 分析表明，这些次级代谢产物的生物合成途径是一种混合异脂肪酸和聚酮合酶途径。