Department of Allergy and Immunology, Heart of England NHS Foundation Trust, Birmingham, UK.
Warwick Medical School, University of Warwick, Warwick, UK.
Allergy. 2015 Dec;70(12):1580-7. doi: 10.1111/all.12702. Epub 2015 Sep 22.
The incidence of anaphylaxis in South Asians (Indian, Pakistani and Bangladeshi ethnicity) is unknown. Birmingham is a British city with a disproportionately large population of South Asians (22.5%) compared with the rest of the UK (4.9%). The main aims of this study were to determine the incidence and severity of anaphylaxis in this population and to investigate the differences between the South Asian and White populations.
A retrospective electronic search of emergency department attendances at three hospitals in Birmingham during 2012 was carried out. Wide search terms were used, medical notes were scrutinized, and the World Allergy Organization diagnostic criteria for anaphylaxis were applied. Patients' age, sex, ethnicity and home postal code were collected, reactions were graded by severity, and other relevant details including specialist assessment were extracted. Multivariate analysis was undertaken using 2011 UK census data.
Age-, sex- and ethnicity-standardized incidence rate of anaphylaxis was 34.5 per 100 000 person-years. Multivariate logistic regression which controlled for the confounders of age, sex and level of socioeconomic deprivation showed that incidence was higher in the South Asian population (OR 1.48, P = 0.005). Incidence rate in the South Asian population was 58.3 cases per 100 000 person-years compared to 31.5 in the White population. South Asian children were more likely to present with severe anaphylaxis (OR 5.31, P = 0.002).
Incidence of anaphylaxis is significantly higher in British South Asians compared to the white population. British South Asian children are at a greater risk of severe anaphylaxis than White children.
南亚人（印度裔、巴基斯坦裔和孟加拉裔）的过敏反应发病率尚不清楚。伯明翰是英国的一个城市，其南亚人（22.5%）的人口比例明显高于英国其他地区（4.9%）。本研究的主要目的是确定该人群中过敏反应的发病率和严重程度，并调查南亚人群与白人群体之间的差异。
对 2012 年伯明翰三家医院急诊科就诊的患者进行了回顾性电子检索。使用了广泛的搜索词，仔细检查了病历，并应用了世界过敏组织过敏反应的诊断标准。收集了患者的年龄、性别、种族和家庭邮政编码，根据严重程度对反应进行分级，并提取了其他相关细节，包括专科评估。使用 2011 年英国人口普查数据进行了多变量分析。
年龄、性别和种族标准化的过敏反应发病率为 34.5/10 万人年。多变量逻辑回归控制了年龄、性别和社会经济剥夺程度的混杂因素，结果表明南亚人群的发病率更高（比值比 1.48，P=0.005）。南亚人群的发病率为 58.3/10 万人年，而白人群体为 31.5/10 万人年。南亚儿童更有可能出现严重过敏反应（比值比 5.31，P=0.002）。
与白人群体相比，英国南亚人群的过敏反应发病率显著更高。英国南亚儿童发生严重过敏反应的风险高于白人儿童。
