Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
Colorectal Dis. 2012 Jun;14(6):e319-22. doi: 10.1111/j.1463-1318.2012.02960.x.
South Asians comprise 13.6% of the Wolverhampton population. We aimed to compare the incidence and trend of colorectal cancer in this subgroup with the non South Asian population over a 20-year period.
Patients of South Asian origin diagnosed with colorectal cancer from 1989 to 2008 were identified from the hospital histopathology database and compared with those of non South Asian origin. 1991 and 2001 census data were used to standardize for differing age and sex distributions in the two study populations.
The median unadjusted incidence of colorectal cancer from 1989 to 2008 was 6.17 per 100,000 per year in South Asians compared with 71.70 per 100,000 per year in non South Asians (77.79% white British). The age and sex adjusted odds ratio for colorectal cancer in South Asians was 0.2 (P < 0.001). There was an equal increased trend in the incidence in both the South Asians and non South Asians over the study period (0.8% per year). In patients < 50 years, the gender difference in the incidence of cancer was not significant, but as age increased this rose significantly (males > females).
There was a markedly lower incidence of colorectal cancer in South Asians compared with non South Asians, maintained over 20 years. Colorectal cancer incidence increased by a small and similar amount over the period in both groups. There was a male preponderance of colorectal cancer in both populations over 50 years.
南亚人占伍尔弗汉普顿人口的 13.6%。我们旨在比较这一亚人群与非南亚人群在 20 年间的结直肠癌发病率和趋势。
从医院组织病理学数据库中确定了 1989 年至 2008 年间诊断为结直肠癌的南亚裔患者，并与非南亚裔患者进行比较。使用 1991 年和 2001 年的人口普查数据对两个研究人群的年龄和性别分布差异进行标准化。
1989 年至 2008 年，南亚裔人群结直肠癌的未经调整中位发病率为每年每 10 万人 6.17 例，而非南亚裔人群为每年每 10 万人 71.70 例（77.79%为英国白人）。南亚裔人群结直肠癌的年龄和性别调整比值比为 0.2（P<0.001）。在研究期间，南亚裔和非南亚裔人群的结直肠癌发病率均呈同等增加趋势（每年 0.8%）。在<50 岁的患者中，癌症发病率的性别差异不显著，但随着年龄的增长，这种差异显著增加（男性>女性）。
与非南亚裔人群相比，南亚裔人群的结直肠癌发病率明显较低，且在 20 年间保持稳定。在两个组中，结直肠癌的发病率在这一期间以较小且相似的幅度增加。在两个人群中，超过 50 岁的人群中结直肠癌都以男性居多。
