Wang Ya, Rui Tian-qi, Yang Jun-hui, Li Jun-son, Zhou Ling-ling, Cai Bao-chang
Zhong Yao Cai. 2015 Jan;38(1):53-7.
To compare the effects of crude and wine-processed Rhei Radix et Rhizoma on upper-energizer disease and hepatic energy metabolism in mice.
The streptococcal pneumonia rats model and acetic acid burning mouth ulcers rats model were established and randomly divided into three groups: model group, crude Rhei Radix et Rhizoma group and wine-processed Rhei Radix et Rhizoma group. The pathologic changes were observed after the rats had been administrated with water extracts of crude and wine-processed Rhei Radix et Rhizoma respectively. The normal ICR mice were randomly divided into three groups: control group, crude Rhei Radix et Rhizoma group and wine-processed Rhei Radix et Rhizoma group. The influence of water extracts of crude and wine-processed Rhei Radix et Rhizoma on the activities of Na+, K-ATPase, Ca2+ -ATPase and succinic dehydrogenase(SDH) in the mice were compared.
Compared with the crude one,the wine-processed Rhei Radix et Rhizoma significantly decreased the inflammation scores (P <0. 05), and promoted the tissue repair of acetic acid burning mouth ulcers rats model. The wine-processed one could also obviously reduce and normalize the level of leucocyte and neutrophilic granulocyte, lower the TNF-α level (P <0. 05), and relieve inflammatory exudation of the lung tissue. The inhibitory effects of wine-processed Rhei Radix et Rhizoma on the activities of SDH, Ca2+-ATPase and Na+, K + -ATPase were weaker than those of the crude one (P > 0. 05).
After having been processed with wine, the efficacy of Rhei Radix et Rhizoma on upper-energizer disease is enhanced, and the inhibition on the activity of energy metabolism enzyme in liver tends to be weakened.
比较生大黄与酒大黄对小鼠上焦病症及肝脏能量代谢的影响。
建立肺炎链球菌大鼠模型和醋酸烧灼口腔溃疡大鼠模型，并随机分为三组：模型组、生大黄组和酒大黄组。分别给予生大黄和酒大黄水提取物后观察大鼠的病理变化。将正常ICR小鼠随机分为三组：对照组、生大黄组和酒大黄组。比较生大黄和酒大黄水提取物对小鼠Na +、K -ATP酶、Ca2 + -ATP酶和琥珀酸脱氢酶（SDH）活性的影响。
与生品相比，酒大黄显著降低炎症评分（P <0.05），促进醋酸烧灼口腔溃疡大鼠模型的组织修复。酒大黄还可明显降低并使白细胞和中性粒细胞水平恢复正常，降低TNF-α水平（P <0.05），减轻肺组织炎症渗出。酒大黄对SDH、Ca2 + -ATP酶和Na +、K + -ATP酶活性的抑制作用弱于生大黄（P >0.05）。
酒制后，大黄对上焦病症的疗效增强，对肝脏能量代谢酶活性的抑制作用趋于减弱。
