Yan Hai-yan, Zou Chun-cai, Wang Xiao-yan, Li Ping, Yang You-yun, Jin Yong
Zhong Yao Cai. 2015 Jan;38(1):58-61.
To study the correlation on chemical fingerprint features between Trichosanthis Fructus and its processed products.
The chemical fingerprints were established by HPLC for the ethyl acetate extraction and the n-butanol extraction in Trichosanthis Fructus and its processed products,the common pattern was established by the mean and the median, and the similarity degree between Trichosanthis Fructus and its processed products was calculated by the correlation coefficient method and the included angle cosine method.
There were 24 common peaks in the fingerprints of ethyl acetate extraction of Trichosanthis Fructus and its processed products,the average similarity degree was calculated separately by the correlation coefficient method and the included angle cosine method:the former as the value was 0. 8497(mean), 0. 8344(median); and the latter as the value was 0. 8429(mean), 0. 8536 (median); there were 6 common peaks in the fingeprints of n-butanol extraction of Trichosanthis Fructus and its processed products, the average similarity degree was calculated by the correlation coefficient method and the included angle cosine method:the former as the value was 0. 9044 (mean), 0. 9076 (median); and the latter as the value was 0. 9075 (mean), 0. 9081 (median).
Main peaks have good correlation between Trichosanthis Fructus and its processed products. This method can provide theoretical basis for processing and quality control of Trichosanthis Fructus.
研究瓜蒌及其炮制品化学指纹图谱特征之间的相关性。
采用高效液相色谱法建立瓜蒌及其炮制品乙酸乙酯提取物和正丁醇提取物的化学指纹图谱，用均值和中位数建立共有模式，采用相关系数法和夹角余弦法计算瓜蒌及其炮制品之间的相似度。
瓜蒌及其炮制品乙酸乙酯提取物指纹图谱中有24个共有峰，用相关系数法和夹角余弦法分别计算平均相似度：前者均值为0.8497，中位数为0.8344；后者均值为0.8429，中位数为0.8536；瓜蒌及其炮制品正丁醇提取物指纹图谱中有6个共有峰，用相关系数法和夹角余弦法计算平均相似度：前者均值为0.9044，中位数为0.9076；后者均值为0.9075，中位数为0.9081。
瓜蒌及其炮制品主要峰之间具有良好的相关性。该方法可为瓜蒌的炮制及质量控制提供理论依据。
