Mukete Bertrand N, Ferdinand Keith C
Tulane Heart and Vascular Institute/Section of Cardiology at Tulane University School of Medicine, New Orleans, LA, USA.
J Clin Hypertens (Greenwich). 2016 Jan;18(1):10-8. doi: 10.1111/jch.12624. Epub 2015 Jul 27.
Older adults are more likely to take more than two medications for medical conditions, and polypharmacy is associated with increased risk of adverse events (fall injury, hyperkalemia and hypokalemia, heart failure, and blood pressure exacerbation), polypharmacy mismanagement, drug-drug interaction, and increased costs. Knowledge of drugs that interact with known antihypertensive agents is paramount to avoiding or reducing adverse events, hospitalizations, and health care dollars. Innovative approaches such as use of a fixed-dose combination pill, ingestible sensor system, electronic reminder system, medical audits, and the integration of a pharmacist in the care of patients should be implemented to avoid polypharmacy mismanagement.
老年人更有可能因医疗状况而服用两种以上药物，而多重用药与不良事件（跌倒损伤、高钾血症和低钾血症、心力衰竭以及血压恶化）风险增加、多重用药管理不善、药物相互作用以及成本增加相关。了解与已知抗高血压药物相互作用的药物对于避免或减少不良事件、住院治疗以及医疗费用至关重要。应采用创新方法，如使用固定剂量复方药丸、可摄入传感器系统、电子提醒系统、医疗审计以及让药剂师参与患者护理，以避免多重用药管理不善。
