Dos Santos Hildemar, Gaio Josileide, Durisic Aleksandra, Beeson W Lawrence, Alabadi Alaa
Department of Healthy Lifestyle and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
Am J Lifestyle Med. 2021 Oct 20;18(6):813-819. doi: 10.1177/15598276211048812. eCollection 2024 Nov-Dec.
Polypharmacy, commonly described as the use of five or more prescribed medications, is a prevalent health issue among seniors because of the potential adverse side effects due to medication interactions. The main purpose of this study was to investigate the association between dietary patterns and number of medications used. We hypothesized that a plant-based diet and healthy lifestyle choices decreases morbidities and number of medications taken. Data on 328 participants, aged 60 years or older, were collected through questionnaires and measurements at the Loma Linda University Drayson Center in Loma Linda, CA, between 2015 and 2016. The dependent variable was the number of pills taken, used as counts, and the main exposure was the type of diet adopted. Negative binomial regression was used for analysis. Results suggest that a vegan diet reduces the number of pills by 58% compared to non-vegetarian (IRR=.42 [95% CI: .25-.70]), even after adjusting for covariates. Increases in age, body mass index (BMI), and presence of disease suggest an increased number of pills taken. A vegan diet showed the lowest amount of pills in this sample. Body mass index also had a significant positive association with the number of pills.
多重用药通常被定义为使用五种或更多的处方药，由于药物相互作用可能产生不良副作用，这是老年人中普遍存在的健康问题。本研究的主要目的是调查饮食模式与用药数量之间的关联。我们假设以植物为基础的饮食和健康的生活方式选择可降低发病率和用药数量。2015年至2016年期间，通过问卷和测量，在加利福尼亚州洛马林达市洛马林达大学德雷森中心收集了328名60岁及以上参与者的数据。因变量是服用的药丸数量，以计数形式呈现，主要暴露因素是所采用的饮食类型。采用负二项回归进行分析。结果表明，即使在调整协变量后，纯素饮食与非素食相比，用药丸数量减少了58%（发病率比=0.42 [95%置信区间：0.25 - 0.70]）。年龄、体重指数（BMI）的增加以及疾病的存在表明用药丸数量增加。在这个样本中，纯素饮食的药丸用量最低。体重指数与药丸数量也存在显著的正相关。
