Satpathy Swaha, Patra Arjun, Ahirwar Bharti
J Complement Integr Med. 2015 Dec;12(4):251-66. doi: 10.1515/jcim-2015-0034.
Postmenopausal osteoporosis, a silent epidemic, has become a major health hazard, afflicting about 50% of postmenopausal women worldwide and is thought to be a disease with one of the highest incidences in senile people. It is a chronic, progressive condition associated with micro-architectural deterioration of bone tissue that results in low bone mass, decreased bone strength that predisposes to an increased risk of fracture. Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which leads to decline in bone formation and increase in bone resorption activity. Estrogen is able to suppress the production of proinflammatory cytokines like interleukin (IL)-1, IL-6, IL-7 and tumor necrosis factor (TNF-α). This is why these cytokines are elevated in postmenopausal women. In this review article we have made an attempt to collate the various methods and parameters most frequently used for screening of antiosteoporotic activity in postmenopausal osteoporosis. Pertaining to ovariectomized animal model, this is the most appropriate model for studying the efficacy of different drugs to prevent bone loss in postmenopausal osteoporosis.
绝经后骨质疏松症是一种悄无声息的流行病，已成为主要的健康隐患，困扰着全球约50%的绝经后女性，被认为是老年人中发病率最高的疾病之一。它是一种慢性、进行性疾病，与骨组织微结构恶化相关，导致骨量降低、骨强度下降，进而增加骨折风险。由于绝经期间雌激素减少，导致骨形成减少和骨吸收活动增加，女性比男性更容易患骨质疏松症。雌激素能够抑制白细胞介素（IL）-1、IL-6、IL-7和肿瘤坏死因子（TNF-α）等促炎细胞因子的产生。这就是这些细胞因子在绝经后女性中升高的原因。在这篇综述文章中，我们试图整理绝经后骨质疏松症抗骨质疏松活性筛查中最常用的各种方法和参数。对于去卵巢动物模型，这是研究不同药物预防绝经后骨质疏松症骨丢失疗效的最合适模型。
