绝经后骨质疏松症：免疫系统细胞的作用。
Postmenopausal osteoporosis: the role of immune system cells.
作者信息
Faienza Maria Felicia, Ventura Annamaria, Marzano Flaviana, Cavallo Luciano
机构信息
Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, Italy.
出版信息
Clin Dev Immunol. 2013;2013:575936. doi: 10.1155/2013/575936. Epub 2013 May 23.
Abstract
In the last years, new evidences of the relationship between immune system and bone have been accumulated both in animal models and in humans affected by bone disease, such as rheumatoid arthritis, bone metastasis, periodontitis, and osteoporosis. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue with a subsequent increase in bone fragility and susceptibility to fractures. The combined effects of estrogen deprivation and raising of FSH production occurring in menopause cause a marked stimulation of bone resorption and a rapid bone loss which is central for the onset of postmenopausal osteoporosis. This review focuses on the role of immune system in postmenopausal osteoporosis and on therapeutic strategies targeting osteoimmunology pathways.
摘要
在过去几年中，动物模型和患有诸如类风湿性关节炎、骨转移、牙周炎和骨质疏松症等骨疾病的人类身上都积累了免疫系统与骨骼之间关系的新证据。骨质疏松症的特征是骨量低和骨组织微结构恶化，随后骨脆性增加且易发生骨折。绝经期间雌激素缺乏和促卵泡生成素分泌增加的综合作用会显著刺激骨吸收并导致快速骨质流失，这是绝经后骨质疏松症发病的关键因素。本综述重点关注免疫系统在绝经后骨质疏松症中的作用以及针对骨免疫学途径的治疗策略。
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