Berin M C
Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Clin Exp Allergy. 2015 Oct;45(10):1483-96. doi: 10.1111/cea.12598.
Food allergy is a prevalent disease for which there is no current treatment beyond careful food avoidance. Accidental exposure to foods causes reactions in allergic individuals that can range in severity from mild skin reactions to severe and life-threatening anaphylaxis, and there are no validated tools to predict severity of reactions. A greater understanding of the pathogenesis of food allergy is needed to develop prevention and treatment strategies for food allergy. In the last few years, there have been significant developments in the field of food allergy that have led to new ideas about food allergy prevention, diagnosis, and treatment. This review will discuss these recent advances in the food allergy field as well as identify gaps in our knowledge about the immune mechanisms of allergy and tolerance to foods.
食物过敏是一种普遍存在的疾病，目前除了谨慎避免食用相关食物外，尚无其他治疗方法。意外接触食物会导致过敏个体产生反应，其严重程度从轻微的皮肤反应到严重的、危及生命的过敏反应不等，而且目前还没有经过验证的工具来预测反应的严重程度。为了制定食物过敏的预防和治疗策略，需要更深入地了解食物过敏的发病机制。在过去几年中，食物过敏领域取得了重大进展，催生了关于食物过敏预防、诊断和治疗的新观念。本综述将讨论食物过敏领域的这些最新进展，并找出我们在食物过敏免疫机制和对食物耐受性方面的知识空白。
