Bosco Antonio, Rinaldi Laura, Cappelli Giovanna, Saratsis Anastasios, Nisoli Lucio, Cringoli Giuseppe
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Regional Center for Monitoring Parasitic Infections (CREMOPAR, Regione Campania), Via della Veterinaria, 1-80137 Naples, Italy.
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Regional Center for Monitoring Parasitic Infections (CREMOPAR, Regione Campania), Via della Veterinaria, 1-80137 Naples, Italy; Interdipartimental Centre of Research in Parasitology-CIRPAR, Italy.
Vet Parasitol. 2015 Sep 15;212(3-4):408-10. doi: 10.1016/j.vetpar.2015.06.034. Epub 2015 Jul 13.
Five controlled field trials were conducted in southern Italy to evaluate the effect of metaphylactic treatment strategies of toltrazuril and diclazuril for the control of coccidiosis in water buffaloes naturally infected by Eimeria spp. The 5 farms were divided into two types (A and B) according to their management system (individual or collective breeding of buffalo calves). In the farms of type A (no. 3), the buffalo calves were bred in individual boxes from the birth to the 7th/8th week of age and then transferred to concrete based pens; in the farms of type B (no. 2) the calves were bred in groups on concrete based pens from the birth. On each farm, 36 calves aged 5 weeks were divided at random into three similar groups of 12. One group was treated with toltrazuril (TOL), the second group was treated with diclazuril (DIC) and the third group was remained as untreated control group (CONT). On each farm the calves were weighed weekly and clinically examined. In the 5 buffalo farms the average oocyst excretion decreased significantly in both the treated groups (TOL and DIC), however the TOL groups had significantly low counts than the DIC groups. The body-weight gains recorded fortnightly were significantly higher in the TOL groups (range=5.4-8.1 kg) compared to the DIC (range=1.7-3.1 kg).
在意大利南部进行了五项对照田间试验，以评估托曲珠利和地克珠利的群体预防治疗策略对控制自然感染艾美耳球虫的水牛球虫病的效果。根据水牛犊牛的饲养管理系统（个体或集体饲养），将这5个农场分为两种类型（A和B）。在A型农场（3号农场），水牛犊牛从出生到7/8周龄在单独的牛栏中饲养，然后转移到水泥地面的围栏中；在B型农场（2号农场），犊牛从出生起就在水泥地面的围栏中成群饲养。在每个农场，将36头5周龄的犊牛随机分为三组，每组12头。一组用托曲珠利（TOL）治疗，第二组用地克珠利（DIC）治疗，第三组作为未治疗的对照组（CONT）。在每个农场，每周对犊牛进行称重并进行临床检查。在这5个水牛农场中，两个治疗组（TOL和DIC）的平均卵囊排泄量均显著下降，然而TOL组的计数显著低于DIC组。与DIC组（范围=1.7-3.1千克）相比，TOL组每两周记录的体重增加显著更高（范围=5.4-8.1千克）。
