Querido S, Jorge C, Sousa H, Birne R, Matias P, Weigert A, Adragão T, Bruges M, Ramos S, Santos M, Paixão P, Curran M D, Machado D
Department of Nephrology, Médio Tejo Hospitalar Center, Torres Novas, Portugal.
Department of Nephrology, Santa Cruz Hospital, Carnaxide, Portugal.
Transpl Infect Dis. 2015 Oct;17(5):732-6. doi: 10.1111/tid.12426. Epub 2015 Sep 21.
We report the case of an isolated JC virus (JCV) infection, without co-infection by polyoma BK virus (BKV), associated with nephropathy 4 years after kidney transplantation. Clinical suspicion followed the observation of a decrease in estimated glomerular filtration rate (eGFR) and a renal allograft biopsy revealing polyomavirus-associated tubulointerstitial nephritis and positivity for SV40. An in-house real-time polymerase chain reaction assay, targeting the presence of JCV and the absence of BKV in biopsy tissue, confirmed diagnosis. Thirteen months after diagnosis, and following therapeutic measures, eGFR remains stable.
我们报告了一例孤立的JC病毒（JCV）感染病例，该病例未合并多瘤BK病毒（BKV）感染，发生于肾移植4年后的肾病患者。临床怀疑源于观察到估计肾小球滤过率（eGFR）下降，以及肾移植活检显示多瘤病毒相关性肾小管间质性肾炎和SV40阳性。一种针对活检组织中JCV的存在和BKV的缺失的内部实时聚合酶链反应检测方法证实了诊断。诊断后13个月，在采取治疗措施后，eGFR保持稳定。
