León-Sicairos Nidia, Angulo-Zamudio Uriel A, de la Garza Mireya, Velázquez-Román Jorge, Flores-Villaseñor Héctor M, Canizalez-Román Adrian
Unidad de Investigación, Facultad de Medicina, Universidad Autónoma de Sinaloa Culiacán, Mexico ; Departamento de Investigación, Hospital Pediátrico de Sinaloa "Dr. Rigoberto Aguilar Pico" Culiacán, Mexico.
Maestría en Ciencias de la Salud, Facultad de Medicina, Universidad Autónoma de Sinaloa Culiacán, Mexico.
Front Microbiol. 2015 Jul 9;6:702. doi: 10.3389/fmicb.2015.00702. eCollection 2015.
Iron is an essential element for the growth and development of virtually all living organisms. As iron acquisition is critical for the pathogenesis, a host defense strategy during infection is to sequester iron to restrict the growth of invading pathogens. To counteract this strategy, bacteria such as Vibrio parahaemolyticus have adapted to such an environment by developing mechanisms to obtain iron from human hosts. This review focuses on the multiple strategies employed by V. parahaemolyticus to obtain nutritional iron from host sources. In these strategies are included the use of siderophores and xenosiderophores, proteases and iron-protein receptor. The host sources used by V. parahaemolyticus are the iron-containing proteins transferrin, hemoglobin, and hemin. The implications of iron acquisition systems in the virulence of V. parahaemolyticus are also discussed.
铁是几乎所有生物生长和发育所必需的元素。由于铁的获取对发病机制至关重要，感染期间的一种宿主防御策略是螯合铁以限制入侵病原体的生长。为了应对这种策略，副溶血性弧菌等细菌通过开发从人类宿主获取铁的机制来适应这种环境。本综述重点关注副溶血性弧菌从宿主来源获取营养性铁所采用的多种策略。这些策略包括使用铁载体和异源铁载体、蛋白酶和铁蛋白受体。副溶血性弧菌利用的宿主来源是含铁蛋白质转铁蛋白、血红蛋白和血红素。还讨论了铁获取系统对副溶血性弧菌毒力的影响。
