Gondim Francisco de Assis Aquino, Tavares Júnior José Wagner Leonel, Morais Arlindo A, Sales Paulo Marcelo Gondim, Wagner Horta Goes
Neurology Division, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
Tremor Other Hyperkinet Mov (N Y). 2015 Jun 23;5:309. doi: 10.7916/D83FaNQ7. eCollection 2015.
Corticobasal syndrome (CBS) is a complex neurodegenerative disorder associated with parkinsonism and alien limb syndrome. Dressing and ideomotor apraxia were reportedly responsive to amantadine.
A 79-year-old female was referred for evaluation of right hemiparesis. Neurological examination showed dementia, normal ocular movements, mild facial hypomimia, and bradykinesia with right hemiparesis. Nine years later, she developed alien limb syndrome and was diagnosed with CBS. After failure to respond to several medications, alien limb syndrome markedly improved with amantadine.
To the best of our knowledge, this is the first report of a consistent response of severe, forced dystonic alien limb syndrome to amantadine in a patient with CBS.
皮质基底节综合征（CBS）是一种与帕金森综合征和异己肢体综合征相关的复杂神经退行性疾病。据报道，穿衣失用症和观念运动性失用症对金刚烷胺有反应。
一名79岁女性因右侧偏瘫接受评估。神经系统检查显示痴呆、眼球运动正常、轻度面部表情减少、运动迟缓伴右侧偏瘫。九年后，她出现了异己肢体综合征，并被诊断为CBS。在对几种药物治疗无效后，金刚烷胺使异己肢体综合征明显改善。
据我们所知，这是首例关于CBS患者严重、强迫性肌张力障碍性异己肢体综合征对金刚烷胺持续有反应的报告。
